{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:19:58Z","timestamp":1790871598465,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to establish the safety of multifetal pregnancy reduction (MFPR) and examine its complications, patient background, and psychological impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, single\u2010arm, prospective intervention study included 10 women who were treated at our institution between April and December 2024. The indications were triplet or higher\u2010order multiple pregnancies, as well as twin pregnancies with serious maternal complications. Procedures were performed between 11 and 13 gestational weeks, and the patients were observed for up to 1\u2009week postoperatively. The primary outcome was the completion ratio at hospital discharge, whereas the secondary outcomes were the survival rate of non\u2010targeted fetuses, the number of adverse events, and the psychological evaluation of the patients at 1\u2009week postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 10 patients, one carried twins, seven carried triplets, and two carried quadruplets; half had received ovulation\u2010induction treatment. The procedure completion rate at discharge was 100%, although one patient required reoperation. The survival rate of non\u2010targeted fetuses was 89.5% (17\/19), and adverse events included vaginal bleeding and complete miscarriage. Maternal state\u2010anxiety scores decreased significantly postprocedure, whereas depression scores remained elevated both before and after the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The completion rate of MFPR using echo\u2010guided transabdominal potassium chloride infusion was high, ensuring short\u2010term maternal safety. Although no serious adverse event other than one case of total miscarriage was observed, a long\u2010term safety evaluation is warranted. Moreover, the emotional burden on patients is high before and after the procedure, necessitating the importance of long\u2010term support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70072","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:09:57Z","timestamp":1759327797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The initial report of prospective study for maternal and fetal outcomes to investigate the safety of multifetal pregnancy reduction in Japan"],"prefix":"10.1111","volume":"51","author":[{"given":"Nao","family":"Wakui","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, Graduate School of Medicine The University of Osaka  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Graduate School of Medicine The University of Osaka  Suita Japan"},{"name":"Children's and Women's Health, Division of Health Science, Graduate School of Medicine The University of Osaka  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Shima","sequence":"additional","affiliation":[{"name":"Clinical Psychology, Graduate School of Human Sciences The University of Osaka  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-8332","authenticated-orcid":false,"given":"Aiko","family":"Okada","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Graduate School of Medicine The University of Osaka  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Miyake","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Graduate School of Medicine The University of Osaka  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Sugao","sequence":"additional","affiliation":[{"name":"Clinical Psychology, Graduate School of Human Sciences The University of Osaka  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Mimura","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Graduate School of Medicine The University of Osaka  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Children's and Women's Health, Division of Health Science, Graduate School of Medicine The University of Osaka  Suita Osaka Japan"},{"name":"Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-7572","authenticated-orcid":false,"given":"Michiko","family":"Kodama","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Graduate School of Medicine The University of Osaka  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15505"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004397"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14827"},{"key":"e_1_2_9_5_1","unstructured":"The Ministry of Health Labor and Welfare Survey and Research Project for Promotion of Child and Child Rearing Support.Research on the risk of abuse in families raising multiple children and the effectiveness of home visitation support.2018[cited 24 April 2025]. Available from:https:\/\/www.mhlw.go.jp\/content\/11900000\/000520465.pdf"},{"key":"e_1_2_9_6_1","unstructured":"Specified report of vital statistics. Number of deliveries by prefectures by single or multiple birth (in Japan).2022[cited 24 April 2025]. Available from:https:\/\/www.e-stat.go.jp\/dbview?sid=0003411624"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000119"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24919"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.024"},{"key":"e_1_2_9_10_1","unstructured":"Health Science Council Subcommittee on Assisted Reproductive Medicine.Report on the development of assisted reproductive medical care system through the donation of sperm eggs and embryos etc.2003[cited 24 April 2025]. Available from:https:\/\/www.mhlw.go.jp\/shingi\/2003\/04\/s0428-5d.html. Appendix 3"},{"key":"e_1_2_9_11_1","unstructured":"American Society of Anesthesiologists.Statement on ASA physical status classification system. [cited April 24 2025]. Available from:https:\/\/www.asahq.org\/standards-and-practice-parameters\/statement-on-asa-physical-status-classification-system"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.2.177"},{"key":"e_1_2_9_13_1","volume-title":"The manual of Japanese version of state\u2013trait anxiety inventory\u2010form JYZ","author":"Tadashi H","year":"2010"},{"key":"e_1_2_9_14_1","first-page":"717","article-title":"New self\u2010rating scale for depression","volume":"27","author":"Shima S","year":"1985","journal-title":"Clin Psychiatry"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0882-7974.12.2.277"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01639.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.33.2.337"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.108074"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.11.018"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1701-2163(15)31023-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.3.617"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.8.2170"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead275"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2020.03078"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.06.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-017-0746-5"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6759"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12690"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:04:39Z","timestamp":1761271479000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/jog.70072"],"URL":"https:\/\/doi.org\/10.1111\/jog.70072","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70072"}}