{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T02:08:42Z","timestamp":1761271722676,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n This retrospective study investigated the relationship between\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n (\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n ) infection and prolonged hospitalization in patients with severe hyperemesis gravidarum (HG). We also aimed to identify other factors associated with extended hospital stays.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed data from 164 patients with severe HG. The patients were initially divided into two groups based on their anti\u2010\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n IgG antibody status (positive vs. negative). Subsequently, a second analysis stratified all patients into a short\u2010stay group (<\u200921\u2009days) and a long\u2010stay group (\u2265\u200921\u2009days).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients who were positive for anti\u2010\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n IgG antibodies had significantly longer hospital stays (median 24 vs. 15\u2009days,\n p<\/jats:italic>\n \u2009=\u20090.032). In a univariate analysis, anti\u2010\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n IgG positivity, higher serum free thyroxine (FT4) levels, and strong urine ketone positivity were all significantly associated with long\u2010term hospitalization. In the subsequent multivariate analysis, anti\u2010\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n IgG positivity emerged as an independent risk factor for prolonged hospitalization (odds ratio 4.67, 95% CI 1.61\u201313.49,\n p<\/jats:italic>\n \u2009=\u20090.004). Although strongly positive urine ketones were also associated with longer hospital stays (median 19 vs. 12\u2009days,\n p<\/jats:italic>\n \u2009=\u20090.001), this was not identified as an independent risk factor (odds ratio 2.169, 95% CI 0.97\u20134.85,\n p<\/jats:italic>\n \u2009=\u20090.059).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our findings suggest that testing for anti\u2010\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n IgG antibodies may help identify patients at a higher risk for a longer hospital stay due to severe HG. Pregnant women who test positive for anti\u2010\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n IgG antibodies may benefit from closer monitoring. Additionally, these results raise the possibility that preconception care could be a preventive measure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70099","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:17:35Z","timestamp":1759814255000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Helicobacter pylori<\/i>\n Infection Is a Risk Factor for Severe Hyperemesis Gravidarum Requiring Prolonged Hospitalization"],"prefix":"10.1111","volume":"51","author":[{"given":"Ryuhei","family":"Kurashina","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nippon Medical School, Musashikosugi Hospital Kawasaki city Kanagawa 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