{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:44Z","timestamp":1787015684178,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["NO. LTGY24H040002"],"award-info":[{"award-number":["NO. LTGY24H040002"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to compare clinical characteristics and evaluate diagnostic biomarkers in ovarian endometriosis, with a focus on thyroid autoimmunity associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of 885 patients (441 ovarian endometriosis cases; 444 benign ovarian tumor controls) was conducted. Clinical parameters, thyroid function markers (FT3, FT4, TSH), thyroid autoantibodies (TPOAb, TGAb), and CA125 levels were analyzed. Multivariate regression and ROC curves assessed diagnostic utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ovarian endometriosis patients exhibited higher dysmenorrhea prevalence (49.7% vs. 15.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), bilateral cysts (26.1% vs. 8.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), endometrial polyps (21.9% vs. 15.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), and uterine fibroids (35.6% vs. 26.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) versus controls. Elevated CA125 (75.3% vs. 10.8%), TPOAb (56.9% vs. 6.5%), and TGAb (68.5% vs. 12.4%) incidences were observed in endometriosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Autoimmune thyroid disease co\u2010occurrence was significantly higher in cases (51% vs. 15%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis identified CA125 (OR\u2009=\u200918.4, 95% CI: 12.5\u201327.6), TPOAb (OR\u2009=\u20092.63, 95% CI: 1.46\u20134.77), and TGAb (OR\u2009=\u20094.03, 95% CI: 2.48\u20136.60) as independent risk factors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.001). ROC analysis revealed AUCs of 0.895 (CA125), 0.793 (TGAb), and 0.736 (TPOAb); their combination achieved superior diagnostic accuracy (AUC\u2009=\u20090.924, sensitivity 88.9%, specificity 84.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large\u2010scale retrospective analysis demonstrates that the integration of serum CA125 with thyroid autoantibodies (TPOAb\/TGAb) generates a synergistic diagnostic signature for ovarian endometriosis, achieving unprecedented discriminative accuracy (AUC 0.924) that significantly surpasses individual biomarker testing. The &gt;\u20093\u2010fold elevated co\u2010occurrence of autoimmune thyroid dysfunction in cases reinforces an underrecognized immune\u2010endocrine interplay in disease pathogenesis. These findings support incorporating thyroid autoimmunity screening into standard diagnostic workups to optimize risk stratification and personalized management pathways for symptomatic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70111","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:49:17Z","timestamp":1760575757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrating Thyroid Autoantibodies With\n                    <scp>CA125<\/scp>\n                    Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients"],"prefix":"10.1111","volume":"51","author":[{"given":"Yufeng","family":"Wang","sequence":"first","affiliation":[{"name":"Graduate School of Zhejiang University of Traditional Chinese Medicine  Hangzhou China"},{"name":"Department of Obstetrics and Gynecology Jiaxing Maternal and Child Health Hospital  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiruo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jiaxing Maternal and Child Health Hospital  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology Jiaxing Maternal and Child Health Hospital  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Jiaxing Maternal and Child Health Hospital  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7514-4100","authenticated-orcid":false,"given":"Xuan","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jiaxing Maternal and Child Health Hospital  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP\/04-23-6805"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.041"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1020827"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054254"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2675966"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14010058"},{"issue":"2","key":"e_1_2_12_8_1","article-title":"Endometriosis, Polycystic Ovary Syndrome, and the Thyroid: A Review","volume":"13","author":"Kirkegaard S.","year":"2024","journal-title":"Endocrine 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Miscarriage","volume":"21","author":"Yan N.","year":"2024","journal-title":"Iranian Journal of Immunology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1655727"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.896152"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040776"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-023-01255-5"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13559"}],"updated-by":[{"DOI":"10.1111\/jog.70161","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000}}],"container-title":["Journal of Obstetrics and Gynaecology 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