{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:20:21Z","timestamp":1773030021946,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Extramedullary plasmacytoma (\n                      <jats:styled-content style=\"fixed-case\">EMP<\/jats:styled-content>\n                      ) most commonly arises in the head and neck, with exceedingly rare involvement of the uterine cervix. Only 16 published cases of cervical\n                      <jats:styled-content style=\"fixed-case\">EMP<\/jats:styled-content>\n                      have been reported since 1949. This study presents the first documented case from Iran and synthesizes all reported cases to analyze clinical patterns, diagnostic pitfalls, and management strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 32\u2010year\u2010old Iranian woman presented with postcoital bleeding after years of intermittent spotting. Comprehensive workup in March 2024, excluded multiple myeloma. Due to her desire for pregnancy, she declined hysterectomy and radiotherapy and underwent cervical conization in June 2024, with concurrent endocervical and endometrial sampling. We also conducted a systematic review of all published cervical EMP cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our analysis of 16 published cervical EMP cases (including present case) demonstrates that clinical presentations are nonspecific, commonly postcoital bleeding or abnormal Pap smears, often leading to initial misdiagnosis. Treatment was highly individualized: 9 patients underwent surgery, 6 received radiotherapy (\u00b1 surgery), and outcomes were generally favorable. Notably, fertility\u2010sparing conization alone was associated with disease\u2010free survival in three young patients, including ours, supporting the feasibility of fertility\u2010sparing strategies under strict surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case contributes critical evidence that organ\u2010sparing management can be oncologically appropriate. Cervical EMP should be considered in differential diagnosis of atypical cervical lesions. In the absence of standardized guidelines, management must be tailored to patient values and anatomical context, not based on general EMP guidelines. Continued reporting of well\u2010documented cases is critical to refine prognostic and therapeutic insights for this ultra\u2010rare entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70130","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:16:56Z","timestamp":1762417016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fertility Preservation in Extramedullary Plasmacytoma of the Uterine Cervix: Global Literature Synthesis and First Case From Iran"],"prefix":"10.1111","volume":"51","author":[{"given":"Farideh","family":"Akbari","sequence":"first","affiliation":[{"name":"Haematology and Oncology Research Center Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raziyeh","family":"Vejdani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maraghe University of Medical Sciences  Tabriz Iran"},{"name":"Shahid Beheshti Hospital Maraghe University of Medical Sciences  Maraghe Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9392-202X","authenticated-orcid":false,"given":"Shabnam","family":"Yaghoubi\u2010Kondelaji","sequence":"additional","affiliation":[{"name":"Women's Reproductive Health Research Center Tabriz University of Medical Science  Tarbiz Iran"},{"name":"Al\u2010Zahran Teaching Hospital Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-1018","authenticated-orcid":false,"given":"Fatemeh","family":"Zarghami","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"National Elites Foundation, Center for International Science &amp; Technology Cooperation (CISTC)  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevil","family":"Ghaffarzadeh\u2010Rad","sequence":"additional","affiliation":[{"name":"Endocrine Research Center Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Vahedi","sequence":"additional","affiliation":[{"name":"Department of Pathology Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Namvar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Tabriz University of Medical Science  Tabriz Iran"},{"name":"Tuberculosis and Lung Disease Research Center Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2011.04.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1886"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4816"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2305::AID-CNCR2>3.0.CO;2-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c070b4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.685070"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2022.101087"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i24.7110"},{"issue":"8","key":"e_1_2_12_10_1","first-page":"554","article-title":"Plasmacytoma of Uterine Cervix. A Case Report and Literature Review","volume":"88","author":"Melero\u2010Cort\u00e9s L. M.","year":"2020","journal-title":"Ginecolog\u00eda y Obstetricia de M\u00e9xico"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1605373"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348909021005"},{"issue":"12","key":"e_1_2_12_13_1","first-page":"e361","article-title":"Primary Plasmacytoma of the Uterine Cervix Treated With Three\u2010Dimensional Conformal Radiotherapy","volume":"49","author":"Huang C. 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