{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:24:06Z","timestamp":1785860646159,"version":"3.56.0"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fk0108671h0002"],"award-info":[{"award-number":["JP24fk0108671h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To clarify the current status of human T\u2010cell leukemia virus type 1 (HTLV\u20101) among pregnant women in Japan, with a focus on its prevalence by age and region and the contribution of horizontal transmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Japan Association of Obstetricians and Gynecologists conducted a nationwide questionnaire survey in 2025, collecting 2024 data from 1935 delivery facilities. Facilities reported total deliveries, HTLV\u20101 carrier cases, and testing details. Information was obtained on birth year, parity, residence, and prior HTLV\u20101 test results for carriers. Carrier prevalence by region and age group was analyzed, and prior negative results in multiparous carriers were used to estimate horizontal transmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Responses were received from 1297 facilities (response rate: 67.0%), covering 461\u2009271 deliveries (67.2% of national births). Among these, 331 HTLV\u20101 carriers were identified (0.07%), with the highest prevalence in Kyushu and Okinawa (0.25%). Carrier prevalence declined in younger cohorts (0.04% in women born \u2265\u20091990 vs. 0.09% before 1990; OR 0.435,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among multiparous carriers, 16.3% had previously tested negative, suggesting horizontal transmission, particularly in urban regions (Kanto, Tokai, Kinki).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prevalence of HTLV\u20101 among pregnant women in Japan has declined, largely due to effective mother\u2010to\u2010child transmission prevention implemented mainly in HTLV\u20101 high\u2010prevalence areas. However, horizontal transmission accounts for a notable percentage of cases, highlighting the need to reinforce preventive education and strategies targeting sexual transmission and unsafe medical or cosmetic practices alongside continued perinatal screening and counseling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70145","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:34:31Z","timestamp":1763714071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decline in Human T\u2010Cell Leukemia Virus Type 1 Pregnant Carriers and Emerging Concerns About Horizontal Transmission: A Nationwide Survey in Japan"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-1782","authenticated-orcid":false,"given":"Manabu","family":"Ogoyama","sequence":"first","affiliation":[{"name":"Division of Maternal and Child Health Japan Association of Obstetricians and Gynecologists  Shinjyuku\u2010ku Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Jichi Medical University  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[{"name":"Division of Maternal and Child Health Japan Association of Obstetricians and Gynecologists  Shinjyuku\u2010ku Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Showa Medical University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Maternal and Child Health Japan Association of Obstetricians and Gynecologists  Shinjyuku\u2010ku Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Nippon Medical School  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Division of Maternal and Child Health Japan Association of Obstetricians and Gynecologists  Shinjyuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa Medical University School of Medicine  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-8881","authenticated-orcid":false,"given":"Kiyonori","family":"Miura","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Nagasaki University Graduate School of Biomedical Science  Nagasaki City Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Sagara","sequence":"additional","affiliation":[{"name":"Division of Maternal and Child Health Japan Association of Obstetricians and Gynecologists  Shinjyuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Ishiwata","sequence":"additional","affiliation":[{"name":"Division of Maternal and Child Health Japan Association of Obstetricians and Gynecologists  Shinjyuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.941647"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01124"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00595"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24086961"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23181"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25239"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.87.152"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2021.097"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10112227"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15102002"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30252-3"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2022.105324"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T06:01:54Z","timestamp":1764136914000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jog.70145"],"URL":"https:\/\/doi.org\/10.1111\/jog.70145","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70145"}}