{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:56:02Z","timestamp":1769680562091,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the association between D\u2010dimer\/fibrinogen ratio (DFR) and outcomes of in\u00a0vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) in normocoagulable women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 869 women undergoing their first single blastocyst frozen\u2010thawed embryo transfer (FET) cycles at Beijing Chao\u2010Yang Hospital. Data were collected from the medical records of FET cycles performed at the reproductive medicine center between January 2016 and November 2022. Eligible participants were normocoagulable women aged 22\u201338\u2009years with a body mass index (BMI) &lt;\u200930\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , those with metabolic or uterine disorders or incomplete records were excluded. The primary outcomes were live birth and miscarriage. Participants were stratified by live birth status to assess the association between DFR and pregnancy outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants were categorized into live birth group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009357) and non\u2010live birth group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009512). Compared to the non\u2010live birth group, the live birth group had lower D\u2010dimer (0.19 vs. 0.23\u2009mg\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and DFR (0.07 vs. 0.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Logistic regression revealed that elevated DFR increased pregnancy failure risk. Receiver operating characteristic (ROC) analysis indicated that DFR predicted live birth with a cut\u2010off value of 0.085. Stratified by this cut\u2010off value, the DFR &gt;\u20090.085 group had a higher miscarriage rate (26.40% vs. 15.04%), a lower clinical rate (46.98% vs. 54.51%), and a lower live birth rate (34.38% vs. 46.31%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A higher pre\u2010pregnancy DFR is associated with adverse pregnancy outcomes in normocoagulable women and may serve as a predictor for IVF\/ICSI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70147","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:02:01Z","timestamp":1768377721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between D\u2010Dimer\/Fibrinogen Ratio and Pregnancy Outcomes in Normocoagulable Women Undergoing Frozen\u2010Thawed Embryo Transfer Cycles: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1935-4313","authenticated-orcid":false,"given":"Lina","family":"Wang","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4883-2335","authenticated-orcid":false,"given":"Huanhuan","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-6569","authenticated-orcid":false,"given":"Wenhui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Beijing Chao\u2010Yang Hospital Capital Medical 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