{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:06:55Z","timestamp":1780506415833,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Preeclampsia is an obstetric complication with morbidity and mortality that occurs after the 20th week of pregnancy. Cadherins, which play a role in trophoblast development and placentation, are blamed for the pathogenesis of this disease and our aim was to investigate the potential of cadherin\u201018 level to predict pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective case\u2013control study, serum cadherin\u201018 levels in the early second trimester of pregnancy (between 15 and 20\u2009weeks of gestation) were compared between pregnant women who developed preeclampsia within a 1\u2010year period and healthy pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 170 pregnant women were included in the study; 85 of them were diagnosed with preeclampsia and 85 of them constituted the healthy control group. Of the patients diagnosed with preeclampsia, 40 were classified as early\u2010onset and 45 as late\u2010onset preeclampsia. The mean age was 30.8\u2009years in the preeclampsia group and 28.7\u2009years in the control group. Serum cadherin\u201018 levels were significantly higher in patients with preeclampsia compared to healthy pregnant women. According to Receiver Operating Characteristic curve analysis, the cut\u2010off value of 1015.9\u2009pg\/mL for the diagnosis of preeclampsia had discriminative power with a sensitivity of 57.6% and specificity of 94.1%. In addition, cadherin\u201018 levels above 1302.5\u2009pg\/mL provided 85.0% sensitivity and 98.5% specificity in predicting early\u2010onset preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cadherin\u201018 level is associated with preeclampsia and may be used as a potential biomarker in the prediction of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70159","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:32:28Z","timestamp":1764840748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cadherin\u201018 and Preeclampsia: A Novel Biomarker With Prognostic Value in the Second Trimester?"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-5414","authenticated-orcid":false,"given":"Neset","family":"Gumusburun","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Istanbul Ayd\u0131n University Faculty of Medicine  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-1835","authenticated-orcid":false,"given":"Sebati Sinan","family":"Urkmez","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ondokuz Mayis University Faculty of Medicine  Samsun Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9662-244X","authenticated-orcid":false,"given":"Yesim Civil","family":"Urkmez","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Samsun Training and Research Hospital  Samsun Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-6262","authenticated-orcid":false,"given":"Sakine Merve","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Samsun University Faculty of Medicine  Samsun Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-0059","authenticated-orcid":false,"given":"Bahtiyar","family":"Ciftci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Samsun Training and Research Hospital  Samsun Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.38136\/jgon.801687"},{"issue":"3","key":"e_1_2_13_3_1","first-page":"135","article-title":"Preeklampsi ve Eklampsi (Gebelik Toksemisi): Patogenez, Tan\u0131 ve Tedavi","volume":"7","author":"Cakir A.","year":"2023","journal-title":"G\u00fcncel Retina Dergisi"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.54393\/pjhs.v5i12.2413"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030668"},{"key":"e_1_2_13_6_1","unstructured":"D. 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