{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:44:27Z","timestamp":1778874267048,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Venous thromboembolism (\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      ), including deep vein thrombosis (\n                      <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>\n                      ) and pulmonary embolism (\n                      <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>\n                      ) carries high risk of adverse maternal and fetal outcomes. This Study aimed to evaluate the effectiveness of low\u2010dose low\u2010molecular\u2010weight heparin (\n                      <jats:styled-content style=\"fixed-case\">LMWH<\/jats:styled-content>\n                      ) combined with low\u2010dose acetylsalicylic acid (\n                      <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                      ) prophylaxis in women with a history of\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 77 pregnant women with a history of VTE (42 DVT, 35 DVT\u2009+\u2009PE) received daily prophylaxis with low\u2010dose LMWH (enoxaparin, 1\u2009\u00d7\u20092000 anti\u2010Xa IU\/0.2\u2009mL) and low\u2010dose\n                      <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                      (100\u2009mg\/day) upon confirmation of pregnancy. Gestational outcomes under prophylaxis were compared with their 256 previous pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      77.9% of the study cases were with maternal risk factors\/comorbidities for thrombosis and obstetric complications. LMWH\u2009+\u2009ASA significantly reduced adverse gestational outcomes (71.9% vs. 46.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), including miscarriage (63.3% to 26%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and preeclampsia (9%\u20131.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022). No thrombotic events occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prophylactic use of low\u2010dose LMWH and low\u2010dose ASA is effective in the prevention of thrombotic events and improves gestational outcomes in women with a VTE history.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70160","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T09:25:51Z","timestamp":1764840351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Management of Pregnancies With a History of Venous Thromboembolism: Low\u2010Dose Low\u2010Molecular\u2010Weight Heparin and Low\u2010Dose Acetylsalicylic Acid Prophylaxis"],"prefix":"10.1111","volume":"51","author":[{"given":"Mehmet Sinan","family":"Beksac","sequence":"first","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine Hacettepe University  Ankara T\u00fcrkiye"},{"name":"Department of Obstetrics and Gynecology Istinye University  Istanbul T\u00fcrkiye"},{"name":"Obstetrics and Gynecology Clinic Liv Ankara Hospital  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-4939","authenticated-orcid":false,"given":"Hanife Guler","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls","author":"Waheed S. 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