{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:00:23Z","timestamp":1769688023602,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the association between uterine tumor localization and lymph node metastasis (LNM) in endometrial cancer through pathological uterine mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study included 427 patients with endometrial carcinoma who underwent total hysterectomy, bilateral salpingo\u2010oophorectomy, and systematic lymphadenectomy. Tumor localization was classified based on a six\u2010site pathological mapping model: isolated lower uterine segment (LUS), LUS\u2009+\u2009corpus, corpus\u2010only, corpus+fundus, fundus\u2010only, and total uterine cavity. LNM patterns and pathological features were compared across sites. Logistic regression was used to determine independent predictors of LNM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The highest LNM rates were observed in tumors involving the LUS\u2009+\u2009corpus (37.0%) and total uterine cavity (32.4%), whereas the lowest rate was seen in corpus\u2010only tumors (10.2%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Tumors in high\u2010risk sites featured significantly higher rates of deep myometrial invasion, substantial LVSI, and high\u2010grade histology. In multivariate analysis, substantial LVSI (OR: 9.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), any LUS involvement (OR: 2.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), aggressive histology (OR: 2.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), and BMI (OR: 1.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025) independently predicted LNM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pathological uterine mapping reveals that LUS involvement is an independent risk factor for lymphatic dissemination in endometrial cancer. Tumor site classification may enhance preoperative risk stratification and guide individualized surgical strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70180","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:23:15Z","timestamp":1767698595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uterine Mapping for Lymph Node Metastasis in Endometrial Cancer: A Multicenter Retrospective Cohort Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-925X","authenticated-orcid":false,"given":"\u015eahin Kaan","family":"Baydemir","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-2704","authenticated-orcid":false,"given":"Hande Nur","family":"\u00d6nc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Ba\u015fp\u0131nar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Etlik Z\u00fcbeyde Han\u0131m Women's Health Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-7476","authenticated-orcid":false,"given":"O\u011fuz Kaan","family":"K\u00f6ksal","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candost","family":"Hanedan","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital University of Health Sciences  Ankara Turkey"},{"name":"Department of Gynecologic Oncology Etlik Z\u00fcbeyde Han\u0131m Women's Health Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vakkas","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Etlik City Hospital University of Health Sciences  Ankara Turkey"},{"name":"Department of Gynecologic Oncology Etlik Z\u00fcbeyde Han\u0131m Women's Health Training and Research Hospital  Ankara 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