{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:00:23Z","timestamp":1769688023583,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the clinical, pathological, and treatment\u2010related factors influencing recurrence and mortality in patients diagnosed with vulvar squamous cell carcinoma (SCC), with a specific focus on the prognostic significance of surgical margin width.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 70 patients with histologically confirmed vulvar SCC treated between 2000 and 2020 at a tertiary academic center. Patients were categorized based on tumor\u2010free surgical margin width (&lt;\u20092\u2009mm, 2\u20138\u2009mm, &gt;\u20098\u2009mm). Demographic, clinical, and histopathological parameters were analyzed using Cox regression and Kaplan\u2013Meier methods to assess their impact on disease\u2010free survival (DFS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age at diagnosis was 68\u2009years, and 74.3% of cases were FIGO stage I. Median DFS and OS were 46 and 56\u2009months, respectively. Age and tumor grade emerged as independent predictors of mortality and recurrence. Surgical margins &lt;\u20092\u2009mm were significantly associated with increased recurrence risk (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), while no significant effect on OS was observed. Margins \u2265\u20092\u2009mm conferred a lower recurrence risk, especially in the 2\u20138\u2009mm group. Lymphovascular space invasion (LVSI) and depth of invasion were significant in univariate analysis but lost significance after adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical margin width, particularly margins &lt;\u20092\u2009mm, is a strong predictor of local recurrence in vulvar SCC. Age and tumor grade are independent predictors of prognosis. These findings highlight the importance of individualized surgical planning and support the development of risk\u2010adapted treatment strategies. Future prospective studies are warranted to refine optimal margin thresholds and improve outcomes, especially in high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70183","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:54:47Z","timestamp":1768377287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Where the Line Is Drawn: The Prognostic Role of Surgical Margins in Vulvar\n                    <scp>SCC<\/scp>"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-9505","authenticated-orcid":false,"given":"Duygu","family":"G\u00fczel","sequence":"first","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Cukurova University  Adana T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Co\u015fan","family":"Terek","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015feg\u00fcl","family":"Besler","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Izmir City Hospital  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcrdeniz","family":"Serin","sequence":"additional","affiliation":[{"name":"Department of Pathology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z\u00fcleyha","family":"\u00d6nal","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Akman","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Zekio\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necmettin","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Pathology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayd\u0131n","family":"\u00d6zsaran","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuri","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology, Department of Obstetrics &amp; Gynecology Ege University  Izmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0833-z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.08.019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2018.09.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174184"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246170"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020389"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.05.054"},{"key":"e_1_2_12_9_1","unstructured":"National Comprehensive Cancer Network (NCCN) \u201cVulvar Cancer 2024 NCCN Clinical Practice Guidelines in Oncology \u201daccessed 31 August 2024 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/vulvar.pdf."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.07.055"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092264"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004486"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164061"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2021-002463"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.06.010"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2020.09.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2021.22.8.2541"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-000526"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010167"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15164110"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001195"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2021.07.005"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-023-03095-8"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.03.013"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.5603\/gpl.98720"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.06.503"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113375"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgc.2025.101757"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14124057"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.05.010"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:10:05Z","timestamp":1769645405000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jog.70183"],"URL":"https:\/\/doi.org\/10.1111\/jog.70183","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70183"}}