{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:01:37Z","timestamp":1773018097751,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>A two\u2010stage surgery for endometrial cancer is associated with a high physical and psychological burden on the patient and possibly increases the risk of subsequent abdominal surgeries. In this study, we aimed to characterize the oncological features of endometrial cancer patients with lymph node\u2010positive and lymph node\u2010recurrent disease who underwent two\u2010stage lymphadenectomy after initial hysterectomy without pelvic and para\u2010aortic lymphadenectomy and were at intermediate or high risk for postoperative recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective study evaluated a total of 37 patients with endometrial cancer who underwent postoperative para\u2010aortic lymphadenectomy between April 2020 and March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow\u2010up duration was 42\u2009months. The 3\u2010year survival rate was 90%, and the 3\u2010year recurrence\u2010free survival rate was 80%. Lymph node metastasis occurred in 13.5% of the patients, of whom 2.7% had skip metastases in the para\u2010aortic lymph nodes only. Histologically, most patients (80%) had endometrioid carcinoma grade 1. Overall recurrence was observed in 16.2%. The median recurrence\u2010free survival time was 20.5\u2009months. Poorly differentiated or non\u2010endometrioid histology was found in 66.6% of the patients. All patients with low\u2010grade endometrioid carcinoma with lymph node metastasis or recurrence had p53 mutations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No patients with lymph node metastasis relapsed during the follow\u2010up period. Two\u2010stage lymphadenectomy may have contributed to the favorable outcomes. However, it is difficult to perform molecular pathological evaluation in all cases preoperatively. Therefore, it is acceptable to perform a hysterectomy and undergo a two\u2010stage lymphadenectomy in minimally invasive surgery according to risk classification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70194","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T05:32:27Z","timestamp":1771219947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Postoperative Para\u2010Aortic and Pelvic Lymphadenectomies for Intermediate\u2010 to High\u2010Risk Endometrial Cancer"],"prefix":"10.1111","volume":"52","author":[{"given":"Asumi","family":"Okumura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Kotaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Kubo\u2010Kaneda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9773-2520","authenticated-orcid":false,"given":"Eiji","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University School of Medicine  Tsu Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"\u201cPatient Annual Report for 2022 Japan Society of Obstetrics and Gynecology \u201d."},{"key":"e_1_2_10_3_1","unstructured":"\u201cganjoho.jp \u201d."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090\u20108258(91)90086\u2010k"},{"key":"e_1_2_10_5_1","first-page":"419","article-title":"Postoperative External Irradiation and Prognostic Parameters in Stage I Endometrial Carcinoma: Clinical and Histopathologic Study of 540 Patients","volume":"56","author":"Aalders J.","year":"1980","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1115"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101438.1997.00005.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525\u20101438.1996.06010038.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901015)60:8 <2035::AID-CNCR2820601515>3.0.CO;2-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19910601)67:11<2791::aid\u2010cncr2820671113>3.0.co;2\u2010s"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(97)70601\u2010x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19941101)74:9<2502::aid\u2010cncr2820740918>3.0.co;2\u20102"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107335"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.2.67"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.10.002"},{"key":"e_1_2_10_16_1","volume-title":"National Comprehensive Cancer Network (NCCN), NCCN Guidelines, version 1.2018: Uterine Neoplasms","author":"Wui\u2010Jin K.","year":"2018"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.02.012"},{"key":"e_1_2_10_18_1","first-page":"121","volume-title":"WHO Classification of Tumours","author":"Carcangui M. 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