{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:27Z","timestamp":1787015547971,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Placenta accreta spectrum (\n                      <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>\n                      ) is linked to severe maternal morbidity and mortality, ranging from severe bleeding to death from placental failure at birth.\n                      <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>\n                      arises when the placenta invades the myometrium abnormally rather than the decidua basalis. Although uterine scarring is known to play a part in the pathophysiology of\n                      <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>\n                      , the fact that it can be observed in women who are nulliparous or who have not had uterine surgery raises the possibility that immunohistological changes may also play a role in the development of\n                      <jats:styled-content style=\"fixed-case\">PAS<\/jats:styled-content>\n                      in addition to anatomical defects. Ki\u201067 and vascular endothelial growth factor (\n                      <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                      ) are crucial for placental angiogenesis and trophoblast invasion. The migration and invasion of cancer cells are especially aided by podocalyxin (\n                      <jats:styled-content style=\"fixed-case\">PCX<\/jats:styled-content>\n                      ) overexpression. In this study, we want to examine\n                      <jats:styled-content style=\"fixed-case\">PCX<\/jats:styled-content>\n                      immunoreactivity in pathology samples from patients with a placenta increta diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the hysterectomy specimens of two groups of patients: those who had a cesarean hysterectomy with a clinical diagnosis of placenta increta, and those who had histopathologically confirmed placenta increta but were not diagnosed with placenta increta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We demonstrated that patients with placenta increta had considerably higher levels of VEGF, Ki\u201067, and PCX immunoreactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In PAS cases undergoing clinical hysterectomy, the increase in PCX immunoreactivity can be used as an immunohistochemical marker to support the diagnosis of PAS in histopathological confirmation of PAS diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70207","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T03:25:50Z","timestamp":1771385150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can Podocalyxin Immunoreactivity Facilitate Histopathological Diagnosis of Placenta Accreta Spectrum (\n                    <scp>PAS<\/scp>\n                    ) Disorders?"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0417-6302","authenticated-orcid":false,"given":"Bahar","family":"Say\u0131t","sequence":"first","affiliation":[{"name":"Dr. Firat University School of Medicine Department of Obstetrics and Gynecology  Elazig T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-7158","authenticated-orcid":false,"given":"Remzi","family":"Atilgan","sequence":"additional","affiliation":[{"name":"Prof. Dr. Firat University School of Medicine Department of Obstetrics and Gynecology  Elazig T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-4980","authenticated-orcid":false,"given":"Melike","family":"Aslan","sequence":"additional","affiliation":[{"name":"Assoc. Prof. Dr. Firat University School of Medicine Department of Obstetrics and Gynecology  Elazig T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-3838","authenticated-orcid":false,"given":"Tuncay","family":"Kulo\u011flu","sequence":"additional","affiliation":[{"name":"Prof. Dr. Firat University School of Medicine Department of Histology and Embriology  Elazig T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-3536","authenticated-orcid":false,"given":"I. 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