{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:02:20Z","timestamp":1773018140492,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K09638"],"award-info":[{"award-number":["22K09638"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K23509"],"award-info":[{"award-number":["24K23509"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Magnesium sulfate (MgSO\n                      <jats:sub>4<\/jats:sub>\n                      ) is widely used for fetal neuroprotection in preterm births before 32\u2009weeks of gestation, yet it remains unclear whether its effect depends on gestational age. S100 calcium\u2010binding protein B (S100B), a protein secreted by astrocytes, is recognized as a biomarker of neural distress. This study aimed to investigate the relationship between antenatal MgSO\n                      <jats:sub>4<\/jats:sub>\n                      administration and umbilical cord serum S100B levels, with a focus on gestational age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included women who delivered between 22\n                      <jats:sup>+0<\/jats:sup>\n                      and 33\n                      <jats:sup>+6<\/jats:sup>\n                      weeks of gestation at a tertiary center. Patients with hypertensive disorders of pregnancy, category 1 cesarean sections, multiple pregnancies, major congenital anomalies, or insufficient MgSO\n                      <jats:sub>4<\/jats:sub>\n                      administration were excluded. Cord blood samples were analyzed for S100B levels using ELISA. Multiple linear regression and restricted cubic spline modeling were performed to assess the association between MgSO\n                      <jats:sub>4<\/jats:sub>\n                      and S100B levels across different gestational ages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 69 eligible patients, MgSO\n                      <jats:sub>4<\/jats:sub>\n                      administration was significantly associated with higher cord serum S100B levels who delivered at \u2265\u200930\u2009weeks of gestation (adjusted estimate 0.39, 95% confidence interval 0.17\u20130.62), but not in those who delivered at &lt;\u200930\u2009weeks (\u22120.12, \u22120.43 to 0.19) in multiple linear regression adjusted for birth weight and antenatal corticosteroids. This association remained consistent across multiple sensitivity analyses. S100B levels exhibited a gestational age\u2010dependent increase in response to MgSO\n                      <jats:sub>4<\/jats:sub>\n                      , peaking at approximately 32\u2009weeks in restricted cubic spline modeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Antenatal MgSO\n                      <jats:sub>4<\/jats:sub>\n                      administration beyond 30\u2009weeks of gestation at delivery is associated with increased fetal S100B levels, suggesting a potential gestational age\u2010specific response.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70208","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T03:44:16Z","timestamp":1771213456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational Age\u2010Dependent Effects of Antenatal Magnesium Sulfate on Fetal\n                    <scp>S100B<\/scp>\n                    Levels: An Observational Study Using Cord Serum"],"prefix":"10.1111","volume":"52","author":[{"given":"Takuma","family":"Shimaya","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-8349","authenticated-orcid":false,"given":"Kazuya","family":"Fuma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-5142","authenticated-orcid":false,"given":"Sho","family":"Tano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9340-7809","authenticated-orcid":false,"given":"Seiko","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ushida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Division of Reproduction and Perinatology, Center for Maternal\u2010Neonatal Care Nagoya University Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kajiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Division of Reproduction and Perinatology, Center for Maternal\u2010Neonatal Care Nagoya University Hospital  Nagoya Japan"},{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041671"},{"key":"e_1_2_13_3_1","article-title":"Magnesium Sulphate for Women at Risk of Preterm Birth for Neuroprotection of the Fetus","volume":"5","author":"Shepherd E. 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