{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:01:43Z","timestamp":1773018103404,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyze factors related to lymph node involvement in patients with squamous vulvar cancer undergoing lymphadenectomy and wide local excision at the University Hospital in Campinas, Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study involving 56 women treated between 2010 and 2022. The primary outcome was inguinal lymph node involvement (positive or negative). Clinical, operative, and pathologic variables were analyzed by appropriate tests. Kaplan\u2013Meier curves were used to determine overall survival rate (OS). A receiver operating characteristic (ROC) curve was created to determine the optimal value of the depth of invasion for predicting node positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 56 women who underwent surgery, node involvement was positive in 18 (32.1%). Where node was positive, the tumors were over 5\u2009cm in 22.2% (versus 2.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035), had an depth of invasion equal to or deeper than 13\u2009mm (13\u2009mm+) in 62.5% (versus 14.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), lymphovascular invasion in 33.3% (versus 11.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), presented disease progression in 44.4% (versus 11.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), and death in 77.8% (versus 31.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). The 5\u2010year OS was 57.1% in the node\u2010negative and 8.6% in the node\u2010positive group, with most events occurring within the first 24\u2009months. Depth of invasion 13\u2009mm\u2009+\u2009increased the risk of node\u2010positivity 11 times (11.37;1.85\u201369.82), showing a predictive negative value of 83.3%, and accuracy of 78.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 13.0\u2009mm cutoff for depth of invasion was independently associated with the risk of having a positive node, with an accuracy of 78.4%. The 5\u2010year OS was 8.6% in the node\u2010positive group, with most events within the first 24\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70215","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:05:23Z","timestamp":1771578323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depth of Invasion of 13\u2009mm or Greater Accurately Predicted the Risk of Having a Node Positivity in Lymphadenectomy for Squamous Vulvar Cancer"],"prefix":"10.1111","volume":"52","author":[{"given":"Rafael Coelho","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9678-4208","authenticated-orcid":false,"given":"Samanta Santos","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Valente","family":"Tozatti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Boneto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Carlos","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-0225","authenticated-orcid":false,"given":"Diama Bhadra","family":"Vale","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000138"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15093"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.03.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05813-x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13880"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.06.013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11041025"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0009"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2024.01.017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.03.013"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.02.005"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488800"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1151"},{"issue":"2","key":"e_1_2_12_15_1","first-page":"545","article-title":"Clinicopathological Prognostic Factors and Patterns of Recurrence in Vulvar Cancer","volume":"29","author":"Woelber L.","year":"2009","journal-title":"Anticancer Research"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.077"},{"issue":"1","key":"e_1_2_12_17_1","first-page":"12","article-title":"Characteristic Features of Recurrences of Squamous Cell Carcinoma of the Vulva","volume":"81","author":"Sznurkowski J. 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