{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:08:34Z","timestamp":1774325314432,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Myotonic dystrophy (MD) has been associated with an increased risk of endometrial cancer (EC) in Western countries; however, data from Japan are limited. This study aimed to evaluate the incidence and clinical characteristics of EC and its precursor lesion, atypical endometrial hyperplasia (AEH), in Japanese patients with MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed medical records of female patients with MD (MD group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) and those with other types of muscular dystrophy (control group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984) treated at a single institution between 2008 and 2023.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EC\/AEH was identified in 5 of 36 patients in the MD group (13.9%), including 3 cases of EC and 2 of AEH, whereas 1 case of EC (1.2%) was observed among 84 control patients, indicating a significantly higher incidence in the MD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). The median age at diagnosis of EC\/AEH in the MD group was 45\u2009years, which was significantly younger than that of non\u2010MD EC\/AEH cases treated during the same period (median 59\u2009years). All surgically treated EC cases were early\u2010stage endometrioid carcinoma and achieved favorable oncological outcomes, although perioperative respiratory complications were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Japanese MD patients have a significantly higher risk of developing EC\/AEH at a younger age compared with non\u2010MD patients. These findings highlight the importance of regular gynecological surveillance in women with MD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70221","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:13:38Z","timestamp":1773000818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Risk of Endometrial Cancer and Precursor Lesions in Patients With Myotonic Dystrophy: A Retrospective Study at a Single Institution in Japan"],"prefix":"10.1111","volume":"52","author":[{"given":"Ruka","family":"Hano","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manaka","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hodaka","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9786-4651","authenticated-orcid":false,"given":"Hisanori","family":"Kobara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneaki","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology and Rheumatology) Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000531"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000645"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000524734"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011425"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70204-1"},{"key":"e_1_2_13_7_1","first-page":"109","article-title":"Predictors of Prognosis in Type 1 Myotonic Dystrophy (DM1): Longitudinal 18\u2010Years Experience From a Single Center","volume":"39","author":"Mazzoli M.","year":"2020","journal-title":"Acta Myologica"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062800"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9395-y"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1796"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117212"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.21150"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2011.09.005"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2013.01.052"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003124"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25145"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25736"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209883"},{"key":"e_1_2_13_20_1","article-title":"Spectrum of Cancers and Their Prognosis Among Patients With Myotonic Dystrophy","volume":"8","author":"Gadalla S. 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