{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:51:59Z","timestamp":1776905519098,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A03J0920"],"award-info":[{"award-number":["2023A03J0920"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to elucidate chemerin's role in gestational diabetes mellitus (GDM)\u2010related fetal endothelial dysfunction and its association with non\u2010invasive hemodynamic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We integrated bioinformatics (GSE87295 dataset,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095\/group), a prospective clinical cohort (30 GDM, 31 controls), and functional in\u00a0vitro experiments. Chemerin and von Willebrand factor (vWF) were quantified by ELISA. Fetal aortic pulse wave velocity (APV) was assessed by Doppler ultrasound. Human umbilical vein endothelial cells (HUVECs) were treated with recombinant chemerin (0\u201340\u2009nM).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Transcriptomic analysis revealed chemerin (RARRES2) co\u2010expression with inflammatory and metabolic genes, with tissue\u2010level mRNA downregulation but pathway activation in GDM. Clinically, GDM exhibited elevated umbilical cord serum chemerin (median [IQR]: 244980.49 [244890.56\u2013245318.24] vs. 244463.32 [244429.48\u2013244589.77] pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and vWF (17727.80 [8267.68\u201340286.38] vs. 11804.38 [2793.55\u201330280.01] ng\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), alongside reduced fetal APV (28.4\u2009\u00b1\u20093.1 vs. 35.2\u2009\u00b1\u20092.8\u2009cm\/s,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Serum chemerin correlated positively with vWF (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.538,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and negatively with APV (r\u2009=\u2009\u22120.493,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). In\u00a0vitro, chemerin induced dose\u2010dependent impairment of HUVEC migration (40% reduction at 40\u2009nM,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and proliferation (35% reduction,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), with concomitant vWF mRNA upregulation (2.1\u2010fold,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated circulating chemerin is associated with fetal endothelial dysfunction in GDM. Discordant mRNA\/protein levels suggest post\u2010transcriptional regulation. Cord blood chemerin may serve as a biomarker of fetal vascular injury, while fetal APV offers a non\u2010invasive clinical tool. CMKLR1 antagonist studies are needed to establish therapeutic potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70263","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:57:06Z","timestamp":1775627826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemerin as a Novel Mediator of Fetal Endothelial Dysfunction in Gestational Diabetes Mellitus: Integration of Bioinformatics, Clinical, and In\u00a0Vitro Evidence"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4328-9329","authenticated-orcid":false,"given":"Shilin","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhou","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihui","family":"ShenTu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/20480040221129232"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.02.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166834"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.09.019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034243"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab687"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.04.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010021\u201002010\u2010y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201018\u20100174"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010175"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14515"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2023.0009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2017.1373080"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2023.159409"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00655"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db22\u20100677"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5547228"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113342"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111578"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02772"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010020\u201001206\u2010w"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2018.01.005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13940"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12176"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.05.030"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010023\u201000924\u20102"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11520"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27936"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.121.313128"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944\u2010018\u20100816\u20103"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.001"}],"container-title":["Journal 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