{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:51:56Z","timestamp":1776905516630,"version":"3.51.2"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Combined large cell neuroendocrine carcinoma (LCNEC) of the endometrium is rare and carries a poor prognosis. A 61\u2010year\u2010old woman with suspected endometrial serous carcinoma was referred to our hospital. Imaging studies staged the disease as stage IIIC1. We performed a total hysterectomy, bilateral salpingo\u2010oophorectomy, omentectomy, and retroperitoneal lymph node dissection. Histopathological examination revealed a combination of LCNEC, endometrioid carcinoma, and multiple lymph node metastases. Postoperative computed tomography showed multiple pulmonary metastases not detected preoperatively. Given the advanced and recurrent nature of the disease, treatment with paclitaxel, carboplatin, and durvalumab was initiated. After the first cycle, the pulmonary metastases disappeared. Maintenance therapy with durvalumab and olaparib was continued because of proficient mismatch repair status. This case demonstrates that durvalumab may be a viable treatment option for endometrial LCNEC, as it is also approved for small cell lung cancer, which shares similarities with neuroendocrine carcinoma.<\/jats:p>","DOI":"10.1111\/jog.70270","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:44:08Z","timestamp":1775627048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined Large Cell Neuroendocrine Carcinoma of the Endometrium Treated With Paclitaxel, Carboplatin, and Durvalumab, Followed by Maintenance Therapy With Durvalumab and Olaparib (\n                    <scp>DUO<\/scp>\n                    \u2010E Regimen): A Case Report"],"prefix":"10.1111","volume":"52","author":[{"given":"Takashi","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Gynecology Saku Central Hospital Advanced Care Center  Saku Nagano Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Sonehara","sequence":"additional","affiliation":[{"name":"Department of Gynecology Saku Central Hospital Advanced Care Center  Saku Nagano Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nabeshima","sequence":"additional","affiliation":[{"name":"Department of Gynecology Saku Central Hospital Advanced Care Center  Saku Nagano Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Shioya","sequence":"additional","affiliation":[{"name":"Department of Gynecology Saku Central Hospital Advanced Care Center  Saku Nagano Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakura","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Gynecology Saku Central Hospital Advanced Care Center  Saku Nagano Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Gynecology Saku Central Hospital Advanced Care Center  Saku Nagano Prefecture Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2019.03.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12881"},{"key":"e_1_2_11_4_1","unstructured":"Uterine Neoplasms \u201cReferenced With Permission From the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Uterine Neoplasms V.2.2026 National Comprehensive Cancer Network Inc. 2025 All Rights Reserved. To View the Most Recent and Complete Version of the Guideline \u201dAccessed December 18 2025 NCCN.org."},{"key":"e_1_2_11_5_1","volume-title":"Guidelines for Treatment of Uterine Body Neoplasm: Japan Society of Gynecologic Oncology (JSGO)","year":"2023"},{"key":"e_1_2_11_6_1","unstructured":"Small Cell Lung Cancer \u201cReferenced With Permission From the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Small Cell Lung Cancer V.2.2026 National Comprehensive Cancer Network Inc. 2025 All Rights Reserved To View the Most Recent and Complete Version of the Guideline \u201dAccessed December 18 2025 NCCN.org."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2025.101008"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.08.2362"},{"key":"e_1_2_11_9_1","unstructured":"Neuroendocrine and Adrenal Tumors \u201cReferenced With Permission From the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Tumors V.3.2025 National Comprehensive Cancer Network Inc. 2025. All Rights Reserved To View the Most Recent and Complete Version of the Guideline \u201dAccessed December 18 2025 NCCN.org."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32222-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2025.08.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30539-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2024.101429"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02132"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70270","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:14:58Z","timestamp":1776903298000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/jog.70270"],"URL":"https:\/\/doi.org\/10.1111\/jog.70270","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70270"}}