{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:52:00Z","timestamp":1776905520103,"version":"3.51.2"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["20181152"],"award-info":[{"award-number":["20181152"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the association between dendritic cell maturation deficits and pain in patients with adenomyosis and explore potential neuro\u2010immune mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Uterine tissues from 24 patients with adenomyosis (AM) and 15 controls were analyzed. Samples from the endometrial\u2010myometrial interface (EMI) and middle myometrium (MM) were tested. To study the expression of nerve fiber marker (PGP9.5), nerve growth factor (NGF), mature DC (CD83+), and immature DC (CD1a+), the team used immunohistochemistry (IHC) and real\u2010time quantitative reverse transcription polymerase chain reaction (qRT\u2010PCR). The correlation between these findings and pain scores was also analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PGP9.5 and NGF expression in both EMI and MM regions were significantly higher in the AM group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), whereas the CD83+\/CD1a+ ratio was reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). A significant negative correlation was observed between PGP9.5 and the CD83+\/CD1a+ ratio (MM:\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.650,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011; EMI:\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.812,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). VAS scores (VAS) were negatively correlated with the CD83+\/CD1a+ ratio (MM:\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.851,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; EMI: r\u2009=\u2009\u22120.814,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), but there was no direct association with NGF. Two\u2010way analysis of variance (ANOVA) revealed that the disease state (AM) was the main factor affecting the proportion of NGF and DC maturation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), whereas anatomical location had no significant impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on our cross\u2010sectional observational study, DC maturation deficits are associated with AM pain, potentially through neuro\u2010immune interactions. However, NGF functions independently of DC. Exploring neuro\u2010immune interactions is a new approach for treating AM\u2010related pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70283","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:42:58Z","timestamp":1776062578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Impaired Dendritic Cell Maturation and Uterine Adenomyosis Pain"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1752-4639","authenticated-orcid":false,"given":"Ziying","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weina","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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