{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:51:58Z","timestamp":1776905518546,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) in adolescents and young adults is difficult to diagnose due to overlap with normal puberty. This study assessed irisin as a biomarker, comparing metabolic and hormonal profiles of hyperandrogenic (HA) and normoandrogenic (NA) phenotypes, determining an optimal cut\u2010off, examining correlations with clinical markers, and identifying predictors of irisin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted involving 120 females aged 13\u201321\u2009years, comprising 60 PCOS patients (38 HA\u2010PCOS, 22 NA\u2010PCOS) and 60 healthy controls. Metabolic and hormonal profiles, including serum irisin, insulin resistance indices, lipid profile, and reproductive hormones were assessed. Data were analyzed using SPSS version 22.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Irisin levels were significantly elevated in HA\u2010PCOS compared to NA\u2010PCOS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Irisin showed positive correlation with BMI, glucose, insulin, HOMA\u2010IR, TAGs, low\u2010density lipoprotein, and luteinizing hormone, and negative correlation with high\u2010density lipoprotein and QUICKI. An irisin threshold of 18.24\u2009ng\/mL demonstrated potential in identifying HA\u2010PCOS (area under curve\u2009=\u20090.802). Multivariate regression identified glucose, TAGs, LH, and HOMA\u2010IR as significant predictors of irisin levels (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.908).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HA\u2010PCOS is marked by more severe metabolic disruption. Irisin may serve as a promising early biomarker for this phenotype and help predict long\u2010term complications linked to metabolic disruption in PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70285","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:51:32Z","timestamp":1776063092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the Role of Irisin as a Biomarker in Adolescent and Young Adult\n                    <scp>PCOS<\/scp>\n                    : A Metabolic and Hormonal Comparison of Hyperandrogenic and Normoandrogenic Phenotypes"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4648-8289","authenticated-orcid":false,"given":"Sadaf","family":"Majeed","sequence":"first","affiliation":[{"name":"College of Medicine Dubai Medical University  Dubai UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8793-3844","authenticated-orcid":false,"given":"Hira","family":"Moin","sequence":"additional","affiliation":[{"name":"NUST School of Health Sciences National University of Sciences and Technology  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0430-961X","authenticated-orcid":false,"given":"Sampana","family":"Fatima","sequence":"additional","affiliation":[{"name":"Shahida Islam Medical and Dental College  Lodhran Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fasih","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Allama Iqbal Open University, AIOU  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasneem","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Shifa College of Medicine Shifa Tameer\u2010e\u2010Millat University  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