{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:59Z","timestamp":1788862379203,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vascular Ehlers\u2013Danlos syndrome (vEDS) is a life\u2010threatening connective tissue disorder that often remains undiagnosed before pregnancy and carries a markedly high risk of maternal mortality. We report the case of a 34\u2010year\u2010old pregnant woman who experienced sudden abdominal pain at 39\u2009weeks of gestation and died shortly after delivery. Autopsy revealed an aortic rupture with histopathological findings suggestive of vEDS. Her family history included her father's sudden vascular death, and her personal history was notable for easy bruising and early\u2010onset varicose veins. Next\u2010generation sequencing\u2010based postmortem genetic testing (PMGT) using formalin\u2010fixed, paraffin\u2010embedded liver tissue confirmed a pathogenic variant in\n                    <jats:italic>COL3A1<\/jats:italic>\n                    . This result facilitated genetic counseling for the family, allowing presymptomatic diagnosis and preventive management, including celiprolol therapy for at\u2010risk relatives. This case underscores the value of PMGT in identifying the underlying cause of unexpected maternal death, particularly when conventional samples are unavailable.\n                  <\/jats:p>","DOI":"10.1111\/jog.70299","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:11:46Z","timestamp":1778127106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatal Aortic Rupture at Term Pregnancy Caused by Vascular Ehlers\u2013Danlos Syndrome Diagnosed by Postmortem Genetic Testing Using Formalin\u2010Fixed, Paraffin\u2010Embedded Tissue"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9014-1103","authenticated-orcid":false,"given":"Mari","family":"Tadakawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Shinshu University Hospital  Matsumoto Japan"},{"name":"Department of Medical Genetics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Clinical Sequencing Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-8592","authenticated-orcid":false,"given":"Hasumi","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyoshi","family":"Mochii","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Tsubata","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8344-7507","authenticated-orcid":false,"given":"Tomoki","family":"Kosho","sequence":"additional","affiliation":[{"name":"Center for Medical Genetics, Shinshu University Hospital  Matsumoto Japan"},{"name":"Department of Medical Genetics Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Division of Clinical Sequencing Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Research Center for Supports to Advanced Science, Shinshu University  Matsumoto Japan"},{"name":"BioBank Shinshu, Shinshu University Hospital  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2021-319828"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/19253621221124800"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.72"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31552"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17893"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.53"},{"key":"e_1_2_11_8_1","volume-title":"GeneReviews [Internet]","author":"Byers P. 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