{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:49Z","timestamp":1788862369293,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Embryo selection in assisted reproduction is pivotal for optimizing pregnancy outcomes. While Day 5 blastocysts are generally preferred due to earlier development, the clinical efficacy of high\u2010quality Day 6 embryos remains debatable, particularly concerning aneuploidy risk and pregnancy loss. This study aims to compare chromosomal euploidy rates and clinical outcomes between Day 5 blastocysts and Day 6 blastocysts after preimplantation genetic testing for aneuploidy (PGT\u2010A).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 349 frozen embryo transfer cycles (Day 5:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009165, Day 6:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009184). All embryos underwent PGT\u2010A using next\u2010generation sequencing. Clinical outcomes, fetal loss, and ploidy status were assessed. Logistic regression identified predictors of fetal loss and aneuploidy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant difference in overall aneuploidy rates was observed between Day 5 and Day 6 embryos (47.9% vs. 48.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.847). However, early fetal loss (&lt;\u200912\u2009weeks) was higher among Day 6 embryos (26.6% vs. 17.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). Regression analysis revealed Day 6 transfer was associated with increased odds of fetal loss (OR\u2009=\u20091.707,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), while greater blastocyst expansion and secondary infertility were protective. Higher FSH levels and inner cell mass (ICM) Grade B were significant predictors of aneuploidy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Top\u2010quality Day 6 embryos demonstrate similar aneuploidy rates to Day 5 embryos but are associated with higher early pregnancy loss. Morphological grading and hormonal markers remain essential adjuncts in embryo selection post\u2010PGT\u2010A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70303","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T07:26:50Z","timestamp":1779262010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Evaluation of Clinical Outcomes and Aneuploidy Risk Between Day 5 and Day 6 Blastocyst: A Retrospective Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Lisong","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine and Genetics Ganzhou Maternal and Child Health Hospital  Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Genetics Ganzhou Maternal and Child 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