{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:48Z","timestamp":1788862368702,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the clinical efficacy and safety of hysteroscopic evacuation and oral estrogen\u2010progestogen therapy (Femoston) in the management of retained products of conception (RPOC) after abortion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective comparative study enrolled 75 women with post\u2010abortion RPOC. Participants were allocated to treatment according to informed preference: 38 received oral Femoston therapy, and 37 underwent hysteroscopic evacuation. Outcomes included duration of vaginal bleeding, time to resumption of menstruation, endometrial thickness after menstrual cleansing, treatment success, and adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the hysteroscopy group, the Femoston group had shorter vaginal bleeding duration and earlier resumption of menstruation. Endometrial thickness after menstrual cleansing was greater in the Femoston group. The Femoston group also had a lower overall rate of recorded adverse outcomes, including infection and adhesions. Both groups showed clinical improvement in intrauterine residual tissue, while hysteroscopic evacuation achieved a numerically higher immediate clearance rate. However, oral Femoston achieved a comparable overall clinical effect without invasive intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both hysteroscopic evacuation and oral Femoston showed clinical benefit in the management of post\u2010abortion RPOC. In selected clinically stable patients, oral Femoston may be a feasible conservative alternative, associated with shorter bleeding duration, earlier resumption of menses, greater endometrial thickness after treatment, and fewer recorded adverse outcomes. These findings should be interpreted cautiously due to the non\u2010randomized design and limited sample size, and further, larger studies with standardized safety and outcome assessment are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70305","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:01:13Z","timestamp":1778130073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Efficacy of Hysteroscopic Evacuation Versus Oral Estrogen\u2010Progestogen Therapy (Femoston) for Retained Products of Conception After Abortion: A Prospective Comparative Study"],"prefix":"10.1111","volume":"52","author":[{"given":"XiaoYan","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics The First Affiliated Hospital of Gannan Medical University  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongYan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Quannan County People's Hospital  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaHui","family":"Peng","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gannan Medical University  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaHao","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate School of Gannan Medical University  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShaoXiang","family":"Gong","sequence":"additional","affiliation":[{"name":"Longnan Campus of Gannan Medical University  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Gannan Medical University  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3137-9628","authenticated-orcid":false,"given":"XiaoYan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The First Affiliated Hospital of Gannan Medical University  Ganzhou City Jiangxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"issue":"5","key":"e_1_2_12_2_1","first-page":"512","article-title":"Analysis of Risk Factors for Uterine Adhesions Complicated by Retained Embryos","volume":"47","author":"Ma Y.","year":"2020","journal-title":"International Journal of Obstetrics and Gynecology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489496"},{"issue":"12","key":"e_1_2_12_4_1","first-page":"1298","article-title":"Current Status and Progress in the Treatment of Embryonic Material Residues","volume":"57","author":"Yang X.","year":"2022","journal-title":"Chinese Medical Journal"},{"issue":"3","key":"e_1_2_12_5_1","first-page":"217","article-title":"Hysteroscopic Management of Retained Products of Conception: A Single Center Observational Study","volume":"11","author":"Alonso Pacheco L.","year":"2019","journal-title":"Facts, Views & Vision in ObGyn"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1427714"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1679736"},{"issue":"12","key":"e_1_2_12_8_1","first-page":"905","article-title":"Analysis of Risk Factors for Endometrial Aspiration Biopsy Failure","volume":"29","author":"Chen S.","year":"2020","journal-title":"Modern Obstetrics and Gynecology Progress"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017183"},{"issue":"6","key":"e_1_2_12_10_1","first-page":"1001","article-title":"Analysis of Factors Affecting Uterine Perforation in Hysteroscopic Surgery","volume":"35","author":"Sheng C.","year":"2020","journal-title":"China Maternal and Child Health Care"},{"issue":"6","key":"e_1_2_12_11_1","first-page":"1","article-title":"Perforation Risk and Intrauterine Devices: Results of the EURAS\u2010IUD 5 Year Extension Study","volume":"22","author":"Barnett C.","year":"2018","journal-title":"European Journal of Contraception & Reproductive Health Care"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"129","article-title":"The Value of MRI in Predicting Intraoperative Risk in Uterine Cesarean Section With Scarred Pregnancy Clearance","volume":"41","author":"Yang F.","year":"2022","journal-title":"Journal of Clinical Radiology"},{"issue":"5","key":"e_1_2_12_13_1","first-page":"549","article-title":"Application Value of Mean Diameter of Fetal Sac in Risk Assessment of Hemorrhage During Cesarean Scar Pregnancy Clearance","volume":"51","author":"Yang X.","year":"2023","journal-title":"Tianjin Medicine"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.651273"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13725"},{"issue":"14","key":"e_1_2_12_16_1","first-page":"153","article-title":"Observation on the Efficacy of Mifepristone Combined With Amniofloxacin in the Treatment of Post\u2010Abortion Uterine Cavity Residue","volume":"15","author":"Li Y.","year":"2021","journal-title":"China Modern Drug Application"},{"issue":"3","key":"e_1_2_12_17_1","first-page":"349","article-title":"Analysis of Clinical Value of Estrogen\u2010Progestin Sequential Medication in Treating Patients With Uterine Cavity Residue After Abortion","volume":"28","author":"Zhou S.","year":"2021","journal-title":"Clinical Medical Engineering"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000378"},{"issue":"9","key":"e_1_2_12_19_1","first-page":"920","article-title":"Analysis of Induced Abortion Rate and Influencing Factors in Chinese Women Within 2\u2009Years After Delivery","volume":"38","author":"Xin Y.","year":"2022","journal-title":"Chinese Journal of Practical Gynecology and Obstetrics"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30315-6"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.01.004"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2016.06.020"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011811"},{"issue":"11","key":"e_1_2_12_24_1","first-page":"1165","article-title":"Comparison of the Effects of Hysteroscopically Monitored Hysterectomy and Electrodesiccation in the Treatment of Type 1 Scarred Pregnancy","volume":"42","author":"Yan M. A.","year":"2020","journal-title":"Journal of Ningxia Medical University"},{"issue":"9","key":"e_1_2_12_25_1","first-page":"101","article-title":"Exploration of the Efficacy of Cesarean Section Scar Pregnancy Using Hysteroscopic Ultrasound\u2010Guided Hysterectomy Combined With Interventional Therapy","volume":"23","author":"Cui X.","year":"2022","journal-title":"China Sick Case"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000023"},{"issue":"9","key":"e_1_2_12_27_1","first-page":"989","article-title":"Research Progress on the Effects of Estrogen, Androgen and Their Receptors on Endometrium","volume":"21","author":"Qian X.","year":"2022","journal-title":"Journal of Difficult Diseases"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0106"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03395-9"},{"issue":"5","key":"e_1_2_12_30_1","first-page":"89","article-title":"Effects of White Lotus Dispersing Tang Combined With Fenmaitung on Endometrium After Surgery for Severe Uterine Adhesions","volume":"12","author":"Cao Y.","year":"2020","journal-title":"China Family Planning and Obstetrics and Gynecology"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.05.050"},{"issue":"2","key":"e_1_2_12_32_1","first-page":"158","article-title":"Effect of Aspirin Combined With Fenmadone on the Prognosis of Severe Uterine Adhesions After Surgery","volume":"41","author":"Li L.","year":"2020","journal-title":"Journal of Hebei Medical University"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:31:34Z","timestamp":1788859894000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jog.70305"],"URL":"https:\/\/doi.org\/10.1111\/jog.70305","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70305"}}