{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:44:41Z","timestamp":1787679881465,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Congenital sodium diarrhea (CSD) is a rare inherited enteropathy. We report a case of non\u2010syndromic CSD (non\u2010sCSD) diagnosed prenatally. Serial ultrasounds from 22\u2009weeks and 5\u2009days to 28\u2009weeks and 6\u2009days revealed progressive rectal dilation (0.80\u20131.86\u2009cm), rectal hyperperistalsis, evolving small bowel dilation with a \u201choneycomb\u201d pattern and polyhydramnios. Projectile meconium expulsion at 28\u2009weeks and 6\u2009days confirmed intrauterine diarrhea. Whole\u2010exome sequencing (WES) on amniotic fluid identified compound heterozygous pathogenic variants in the\n                    <jats:italic>SLC9A3<\/jats:italic>\n                    gene, confirming the diagnosis. To our knowledge, this is the first antenatally diagnosed and genetically confirmed case of\n                    <jats:italic>SLC9A3<\/jats:italic>\n                    \u2010related non\u2010sCSD. This case demonstrates that the integration of serial prenatal ultrasonography, specifically tracking progressive rectal dilation and hyperperistalsis, with WES may enable the early antenatal diagnosis of\n                    <jats:italic>SLC9A3<\/jats:italic>\n                    \u2010related non\u2010sCSD. This approach provides critical information for prognosis, perinatal management, and family genetic counseling.\n                  <\/jats:p>","DOI":"10.1111\/jog.70306","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:11:13Z","timestamp":1780985473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal Diagnosis of Non\u2010Syndromic Congenital Sodium Diarrhea by Serial Ultrasonography and Whole\u2010Exome Sequencing: A Case Report and Brief Review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5897-2561","authenticated-orcid":false,"given":"Guishuang","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Chengdu Fifth People's Hospital\/The Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu 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Hospital\/The Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine  Chengdu 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