{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:49Z","timestamp":1788862369285,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We conducted a 24\u2010cycle study to evaluate long\u2010term safety of 4\u2009mg of drospirenone (DRSP), a progestin\u2010only pill (POP), for contraception in Japanese women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter, single\u2010arm 24\u2010cycle study was conducted in women who participated in the 13\u2009cycle study of DRSP. In each cycle, 4\u2009mg of DRSP tablet was administered orally once daily for 24 consecutive days, followed by a placebo tablet for 4\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this 24\u2010cycle study, the total number of DRSP exposure cycles was 3878. Fifty\u2010two subjects (100.0%) experienced treatment\u2010emergent adverse events (TEAEs), and 50 (96.2%) experienced adverse drug reactions. All TEAEs were mild or moderate with no severe events. The most common TEAE was intermenstrual bleeding, which occurred in 49 (94.2%) subjects. Although 50.0% of the subjects had risk factors for venous thromboembolism (VTE), no VTE\u2010related TEAEs were observed. No TEAEs led to discontinuation of the study. During 3878 exposure cycles, pregnancy occurred in one subject. The overall Pearl index [95% CI] was 0.34 [0.01, 1.87], and the cumulative pregnancy rate was 0.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, the safety of DRSP, the first POP in Japan, was evaluated in Japanese women for 24\u2009cycles. The DRSP\u2010only pill provides a new option for contraception for Japanese women, including those at risk of developing VTE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70309","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:39:02Z","timestamp":1779176342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of a 24\u2010Cycle Administration of a Drospirenone\u2010Only Pill in Japanese Women"],"prefix":"10.1111","volume":"52","author":[{"given":"Kunio","family":"Kitamura","sequence":"first","affiliation":[{"name":"Japan Family Planning Association  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Colli","sequence":"additional","affiliation":[{"name":"Exeltis  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Kikuyama","sequence":"additional","affiliation":[{"name":"ASKA Pharmaceutical Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kurihara","sequence":"additional","affiliation":[{"name":"ASKA Pharmaceutical Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieko","family":"Azuma","sequence":"additional","affiliation":[{"name":"ASKA Pharmaceutical Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Kagawa","sequence":"additional","affiliation":[{"name":"ASKA Pharmaceutical Co., Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"UNFPA \u201cSexual and Reproductive Health and Right: An Essential Element of Universal Health Coverage \u201dhttps:\/\/www.unfpa.org\/sites\/default\/files\/pub\u2010pdf\/SRHR_an_essential_element_of_UHC_2020_online.pdf."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011039"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12103388"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80129-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90888-1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03270200017021"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.769187"},{"key":"e_1_2_13_9_1","volume-title":"Progestin\u2010Only Pills. 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