{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:43Z","timestamp":1788862363802,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["0401\u201010"],"award-info":[{"award-number":["0401\u201010"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Concerns about possible adverse events remain a critical barrier in implementing human papillomavirus (HPV) vaccination among Japanese youth. This study aimed to understand the time course of adverse events experienced by HPV vaccine recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An online questionnaire survey was given to students, faculty, and staff aged 18\u201326\u2009years, at Okayama University Hospital, who received the HPV vaccine. The survey gathered information on the number of HPV vaccine doses received, prevaccination health conditions, adverse reactions within 2\u2009h and between 2\u2009h and 7\u2009days postvaccination, menstrual irregularities after vaccination, reasons for getting vaccinated, feelings before and after vaccination, and factors providing reassurance during vaccination. Prevalence of symptoms was expressed as numbers and percentages, and analyses were performed using Chi\u2010squared or Fisher's exact tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Responses were obtained from 299 participants, yielding a 75% response rate. Approximately 60% participants reported local pain, 30% swelling, and 4% fever. Most symptoms resolved on the vaccination day itself or the following day, although some persisted for 3\u20137\u2009days. Over 80% participants rated their pain between 0 and 3 on numerical rating scale of 0\u201310. While 60% experienced anxiety before vaccination, 90% reported no anxiety afterward.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study presents one of the first comprehensive accounts of post\u2010HPV vaccination adverse events and their time course, and underpins the importance of disseminating detailed information about vaccine\u2010associated adverse reactions to encourage greater vaccine uptake.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70314","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T01:14:41Z","timestamp":1779066881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survey to Document the Adverse Reactions After Human Papillomavirus Vaccination Among Japanese Female Youth at a University"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3900-6795","authenticated-orcid":false,"given":"Chigusa","family":"Higuchi","sequence":"first","affiliation":[{"name":"Educational and Research Management Field, Health Management Department Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Okayama University Graduate School of Medicine  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Educational and Research Management Field, Health Management Department Okayama University  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideharu","family":"Hagiya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Masuyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Okayama University Graduate School of Medicine  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Cancer Registry and Statistics \u201cNational Cancer Center Japan: Cancer Information Service \u201d[Cited 8 Apr 2024] https:\/\/ganjoho.jp\/reg_stat\/statistics\/data\/dl\/index.html#a7."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.16020"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15320"},{"key":"e_1_2_13_5_1","unstructured":"World Health Organization \u201cGlobal Partners Cheer Progress Towards Eliminating Cervical Cancer and Underline Challenges \u201d2023 https:\/\/www.who.int\/news\/item\/17\u201011\u20102023\u2010global\u2010partners\u2010cheer\u2010progress\u2010towards\u2010eliminating\u2010cervical\u2010cancer\u2010and\u2010underline\u2010challenges."},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.16167"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13060590"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1986333"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.03.061"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2018.02.002"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2024.11.004"},{"key":"e_1_2_13_12_1","unstructured":"World Health Organization \u201cImmunization Stress\u2010Related Response: A Manual for Program Managers and Health Professionals to Prevent Identify and Respond to Stress\u2010Related Responses Following Immunization 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