{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:48Z","timestamp":1788862368651,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We had defined the anti\u2010M\u00fcllerian hormone (AMH) cut\u2010off value level 2 aligned with the Rotterdam\/International Evidence\u2010based Guideline (IEBG) for the Assessment and Management of polycystic ovary syndrome (PCOS) 2023 criteria. In this study, we evaluated the utility of AMH cut\u2010off value level 2 in patients who could not be diagnosed under the Japan Society of Obstetrics and Gynecology (JSOG) 2024 criteria due to the absence of endocrinological abnormalities and estimated the utility of a new diagnostic approach combining the JSOG 2024 and the Rotterdam\/IEBG 2023 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Through a nationwide survey in Japan, data were collected for 270 patients with irregular menstrual cycles and an antral follicle count of \u2265\u200910 to assess the new diagnostic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 270 patients, 213 (78.9%) met the JSOG 2024 criteria due to the presence of endocrinological abnormalities. Of the remaining 57 patients (21.1%) who did not meet the JSOG 2024 criteria, 36 (63.2%) were additionally diagnosed with PCOS under the Rotterdam\/IEBG 2023 criteria by applying elevated serum AMH (level 2). Consequently, the diagnostic rate of PCOS increased by 16.9% (obese\/overweight: 9.8%, non\u2010obese\/overweight: 19.7%), and the overall diagnostic rate reached 92.2%. The diagnostic rate of this new diagnostic approach was significantly higher than that of the JSOG 2024 or the Rotterdam\/IEBG 2023 criteria alone. Patients additionally diagnosed by this new diagnostic approach were significantly older and had a higher prevalence of oligomenorrhea and lower prevalence of amenorrhea compared with those diagnosed under the JSOG 2024 criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Applying elevated serum AMH (level 2) based on the Rotterdam\/IEBG 2023 criteria improved the diagnostic rate of PCOS, particularly in non\u2010obese\/overweight patients and relatively older women with milder PCOS phenotypes. This new approach is practical, complementary, and can help overcome limitations of the diagnosis of PCOS and thus expand diagnostic opportunities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70326","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:12:13Z","timestamp":1778127133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New Diagnostic Strategy for Polycystic Ovary Syndrome Combining Japanese and International Diagnostic Criteria Using Anti\u2010M\u00fcllerian Hormone"],"prefix":"10.1111","volume":"52","author":[{"given":"Hiroki","family":"Noguchi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences Tokushima University  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-5687","authenticated-orcid":false,"given":"Takeshi","family":"Iwasa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences Tokushima University  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0031-884X","authenticated-orcid":false,"given":"Akira","family":"Iwase","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-8109","authenticated-orcid":false,"given":"Haruhiko","family":"Kanasaki","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Faculty of Medicine Shimane University  Matsue Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Kugu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (Narita Campus) International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Maternal Medicine (Ibaraki), Graduate School Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sapporo Medical University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuaki","family":"Hara","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine Hiroshima Prefectural Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yoshinogawa Medical Center  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30642-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2022.12.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.04.004"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012608"},{"issue":"1","key":"e_1_2_13_6_1","first-page":"165","article-title":"Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women","volume":"84","author":"Legro R. 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