{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:47Z","timestamp":1788862367837,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Placenta accreta spectrum (PAS) is a major obstetric emergency associated with massive hemorrhage, peripartum hysterectomy, and maternal morbidity. This study aimed to evaluate the diagnostic and prognostic value of platelet indices in PAS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective study was conducted at Ankara Etlik City Hospital between August 2022 and August 2024. A total of 200 pregnant women were divided into three groups: PAS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200963), placenta previa (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200967), and controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970). Maternal demographics, delivery outcomes, neonatal parameters, and laboratory results were analyzed. Platelet indices\u2014platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet large cell ratio (P\u2010LCR)\u2014were obtained from first trimester and preoperative blood counts. Receiver operating characteristic (ROC) analysis determined predictive cut\u2010off values. Multivariate logistic regression was performed to identify independent predictors of hysterectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      First\u2010trimester MPV &lt;\u200910.45 demonstrated the highest discriminatory performance for predicting peripartum hysterectomy (AUC\u2009=\u20090.709, sensitivity 70.9%, specificity 71.4%). Third\u2010trimester MPV, PDW, and P\u2010LCR also showed moderate predictive value. First\u2010trimester PDW\u2009&gt;\u200912.75 predicted postpartum hemorrhage (AUC\u2009=\u20090.678), while PDW\u2009&gt;\u200912.35 was associated with composite adverse neonatal outcomes (AUC\u2009=\u20090.597). In placenta previa patients, first\u2010trimester PCT &lt;\u20090.26 predicted PAS (AUC\u2009=\u20090.627). In multivariate analysis, only first\u2010trimester MPV remained independently associated with hysterectomy (aOR 0.647, 95% CI 0.428\u20130.979;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Platelet indices show statistically significant but moderate associations with adverse outcomes in PAS. First\u2010trimester MPV may serve as an early adjunctive marker in high\u2010risk pregnancies; however, these parameters should not replace imaging modalities and require validation in prospective multicenter studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70328","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:58:48Z","timestamp":1778633928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic and Prognostic Value of Platelet Indices in Placenta Accreta Spectrum"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-2850","authenticated-orcid":false,"given":"G\u00fclsan","family":"Karabay","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Ankara Etlik City Hospital  Ankara 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