{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:12:47Z","timestamp":1788862367219,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cervical large\u2010cell neuroendocrine carcinoma (LCNEC) is a rare and highly aggressive malignancy with poor prognoses, particularly in advanced or recurrent disease. We describe a case of advanced and recurrent cervical LCNEC in which long\u2010term disease\u2010free survival was achieved following a systemic\u2010first, sequential multimodal treatment strategy. A 41\u2010year\u2010old woman presented with abnormal vaginal bleeding and was diagnosed with cervical LCNEC with pelvic and para\u2010aortic lymph node metastases. Neoadjuvant irinotecan\u2013cisplatin chemotherapy resulted in marked tumor regression, enabling radical hysterectomy. Postoperative therapy consisted of etoposide\u2013cisplatin chemotherapy, followed by pelvic and para\u2010aortic radiotherapy. Mediastinal lymph node recurrence developed 3\u2009years later and was successfully treated using the same chemotherapy regimen combined with site\u2010directed radiotherapy, resulting in complete remission. The patient remained disease\u2010free 9\u2009years after the final treatment completion. This case suggests that carefully sequenced systemic chemotherapy, surgery, and radiotherapy integration may provide durable disease control in selected patients with advanced or recurrent cervical LCNEC.<\/jats:p>","DOI":"10.1111\/jog.70341","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:25:39Z","timestamp":1779171939000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010Term Disease\u2010Free Survival After Systemic\u2010First Sequential Multimodal Therapy for Advanced and Recurrent Large\u2010Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Case Report"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0874-8888","authenticated-orcid":false,"given":"Kimio","family":"Wakana","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Akita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Tsubata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kori","sequence":"additional","affiliation":[{"name":"Department of Perinatal and Maternal Medicine (Ibaraki) Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamami","family":"Odai","sequence":"additional","affiliation":[{"name":"Department of Women's Health Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Miyasaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/or.2023.11764"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.04.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104447\u2010x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2036361320968401"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gynor.2013.12.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.14740\/jcgo432w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102019\u2010000504"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2003.01.501"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447\u20100756.2007.00509.x"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70341","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:31:22Z","timestamp":1788859882000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jog.70341"],"URL":"https:\/\/doi.org\/10.1111\/jog.70341","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70341"}}