{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:30:36Z","timestamp":1787239836185,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of irisin on the Wnt\/\u03b2\u2010catenin signaling pathway in the endometrium of obese rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010two female Sprague Dawley rats of 5\u2009weeks old were randomly divided into the normal group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and obese group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948). The obese group was fed a high\u2010fat diet, while the normal group was fed a conventional diet. After successful modeling, obese rats were randomly divided into the model group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and irisin group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924). The irisin group was given an intraperitoneal injection of recombinant irisin every day, while the model group and the normal group were intraperitoneally injected with an equal volume of normal saline. Then, female rats in estrus were mated with male rats. Twelve rats were sacrificed in each group on Day 5 and day 10 of pregnancy. The pregnancy rate, average number of blastocysts, histological and morphological changes were observed; the expression of Leukemia Inhibitory Factor (LIF), integrin \u03b1v\u03b23, Wnt4, and \u03b2\u2010catenin in the uterus of rats was detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the normal group, levels of pregnancy rate, average number of blastocyst, LIF, integrin \u03b1v\u03b23, Wnt4, and \u03b2\u2010catenin in the endometrium of the model group rats were significantly decreased. After irisin intervention, compared with the model group, levels of pregnancy rate, average number of blastocyst, LIF, integrin \u03b1v\u03b23, Wnt4, and \u03b2\u2010catenin in the endometrium of the irisin group were significantly increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Irisin may improve endometrial receptivity in obese rats, potentially involving the regulation of the Wnt\/\u03b2\u2010catenin signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70348","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:33:57Z","timestamp":1780032837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Irisin Improves Endometrial Receptivity in Obese Rats Through the\n                    <scp>Wnt\/\u03b2<\/scp>\n                    \u2010Catenin Signaling Pathway"],"prefix":"10.1111","volume":"52","author":[{"given":"Li","family":"Zhou","sequence":"first","affiliation":[{"name":"Xingtai Medical College  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xingtai Medical College  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xingtai Medical College  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Xingtai Medical College  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-7970","authenticated-orcid":false,"given":"Cheng\u2010gang","family":"Li","sequence":"additional","affiliation":[{"name":"Xingtai Medical College  Xingtai Hebei China"},{"name":"The Second Affiliated Hospital of Xingtai Medical College  Xingtai Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_15_2_1","article-title":"Global Obesity Epidemic and Rising Incidence of Early\u2010Onset Cancers","volume":"11","author":"Chen J.","year":"2024","journal-title":"Journal of Global Health"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530320666200515112853"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17142281"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2023.102393"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.04.036"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.80189"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.01.017"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa051"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25136855"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-025-00629-9"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0336-z"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.03.021"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.01.002"},{"key":"e_1_2_15_15_1","first-page":"689","article-title":"Irisin\/FNDC5\u2014An Updated Review","volume":"20","author":"Panati K.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2024.107516"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.12.017"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16602-z"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00524"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.221"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2015-1292"},{"key":"e_1_2_15_22_1","first-page":"1046","article-title":"Irisin Reduces the Abnormal Reproductive and Metabolic Phenotypes of PCOS by Regulating the Activity of Brown Adipose Tissue in Mice","volume":"107","author":"Zheng Y. 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