{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:47:37Z","timestamp":1782186457820,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postpartum depression (PPD) is a common mental health condition affecting women after childbirth and has been linked to long\u2010term health outcomes. However, it remains unclear whether PPD is associated with accelerated aging and increased burden of aging\u2010related diseases later in life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross\u2010sectional analysis among 38\u2009551 parous women from the UK Biobank. Phenotypic biological aging was assessed using two aging clocks, PhenoAge and Klemera\u2013Doubal biological age (KDMAge), derived from clinical biomarkers. Age acceleration was quantified as standardized BAGs after regressing biological age on chronological age. Aging\u2010related disease burden was defined as the presence of at least one of 69 chronic diseases mapped to molecular hallmarks of aging. Multivariable logistic regression models were used to examine associations between PPD and phenotypic BAGs or aging\u2010related disease phenotypes. Subgroup analyses were conducted across demographic, socioeconomic, and lifestyle factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women with a history of PPD showed modestly higher phenotypic aging measures than women without PPD. PPD was associated with higher PhenoAge BAGs and KDMAge BAGs, as well as a higher likelihood of having at least one aging\u2010related disease. These associations were largely consistent across socioeconomic strata defined by education, employment, and Townsend Deprivation Index. Subgroup analyses demonstrated similar patterns across demographic and lifestyle factors, with limited evidence of effect modification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PPD was associated with modestly accelerated biological aging and a greater burden of aging\u2010related diseases in later life. These findings suggest that postpartum mental health may have long\u2010term implications for systemic aging processes and women's health trajectories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70363","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:55:31Z","timestamp":1781070931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Postpartum Depression With Phenotypic Biological Aging and Aging\u2010Related Diseases in Midlife Women"],"prefix":"10.1111","volume":"52","author":[{"given":"Jingxi","family":"Zhu","sequence":"first","affiliation":[{"name":"Suzhou Vocational Health College  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jiangyin People's Hospital  Wuxi Jiangsu 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