{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:01:25Z","timestamp":1784700085627,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n To evaluate the efficacy and underlying mechanisms of dental pulp stem cells (DPSCs), alone or with Jiarong Tablets, for the treatment of intrauterine adhesions (IUAs) in rats.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n IUAs were induced in Sprague Dawley (SD) rats. The rats were randomly assigned to the following groups (\n n<\/jats:italic>\n \u2009=\u200918\/group): Sham, IUA, IUA\u2009+\u2009Estrogen, IUA\u2009+\u2009low\u2212\/medium\u2212\/high\u2010dose DPSC (5\u2009\u00d7\u200910\n 5<\/jats:sup>\n , 1\u2009\u00d7\u200910\n 6<\/jats:sup>\n and 2\u2009\u00d7\u200910\n 6<\/jats:sup>\n cells), IUA\u2009+\u2009DPSC\u2009+\u2009Estrogen (1\u2009\u00d7\u200910\n 6<\/jats:sup>\n DPSCs\u2009+\u2009estradiol (E2)), and IUA\u2009+\u2009DPSC\u2009+\u2009Jiarong Tablets (1\u2009\u00d7\u200910\n 6<\/jats:sup>\n DPSCs +40\u2009mg\/mL Jiarong Tablet administered by gavage). At 28\u2009days post\u2010establishment, the rats were sacrificed (\n n<\/jats:italic>\n \u2009=\u200912\/group) and assessed for endometrial morphology, gland count, fibrosis, serum E2 levels, and PKH26\u2010labeled DPSC tracking, and protein and mRNA analyses of connective tissue growth factor (CTGF), estrogen receptor alpha 1 (ESR1), transforming growth factor beta 1 (TGF\u2010\u03b21), and vascular endothelial growth factor (VEGF) were conducted. Fertility was evaluated on gestational Day 14 after mating (\n n<\/jats:italic>\n \u2009=\u20096\/group).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with the rats in the sham group, the rats in the IUA group exhibited uterine occlusion, a reduced number of endometrial glands, increased fibrosis, decreased serum E2 levels (\n p<\/jats:italic>\n \u2009<\u20090.01), and more irregularly shaped glands (\n p<\/jats:italic>\n \u2009<\u20090.05). Treatment with DPSCs (all doses) and combination therapies significantly improved uterine morphology and reduced fibrosis and E2 levels (\n p<\/jats:italic>\n \u2009<\u20090.05). Treatment with low\u2010 and medium\u2010dose DPSCs increased gland count (\n p<\/jats:italic>\n \u2009<\u20090.05), whereas treatment with DPSCs\u2009+\u2009Jiarong Tablet reduced the number of irregularly shaped glands (\n p<\/jats:italic>\n \u2009<\u20090.01). The fluorescence intensity of DPSCs was dose\u2010dependent in uterine and ovarian tissues (\n p<\/jats:italic>\n \u2009<\u20090.05). The occurrence of IUAs significantly increased the expressions of CTGF, TGF\u2010\u03b21, and VEGF, which were reversed following treatment (\n p<\/jats:italic>\n \u2009<\u20090.05). ESR1 expression was significantly increased after treatment with DPSC and Jiarong Tablet (\n p<\/jats:italic>\n \u2009<\u20090.05). Fertility outcomes improved significantly in all treatment groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n DPSCs were used to effectively treat IUAs, with 1\u2009\u00d7\u200910\n 6<\/jats:sup>\n cells being identified as the optimal dose. Combining DPSCs with Jiarong Tablets further enhanced the therapeutic outcomes by modulating the levels of fibrosis\u2010related factors (CTGF, TGF\u2010\u03b21) and angiogenesis factor (VEGF) and estrogen response (ESR1).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70389","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:43:16Z","timestamp":1782474196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Strategy Using Dental Pulp Stem Cells and Jiarong Tablets to Treat Intrauterine Adhesions in Rats"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6565-4096","authenticated-orcid":false,"given":"Yan\u2010Hong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gynecology Endocrinology Xi'an International Medical Center Hospital Affiliated to Northwest University Xi'an China"},{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of the Air Force Medical University (Xijing Hospital) Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gynecology Endocrinology Xi'an International Medical Center Hospital Affiliated to Northwest University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tong","family":"Liang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical Academy of Shaanxi University of Chinese Medicine Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Endocrinology Xi'an International Medical Center Hospital Affiliated to Northwest University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Clinical Medical Academy of Shaanxi University of Chinese Medicine Xianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4944-4457","authenticated-orcid":false,"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology The Air Force Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-3593","authenticated-orcid":false,"given":"Changhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of the Air Force Medical University (Xijing Hospital) Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815\u2010020\u201001801\u2010x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1142\/9789811228063_0008"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S165474"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.03.021"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.47191\/ijmscrs\/v3\u2010i10\u201027"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201002756\u20109"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201003989\u20106"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2025.03.019"},{"key":"e_1_2_13_10_1","first-page":"28","article-title":"The Therapeutic Effects of Stem Cells From Human Exfoliated Deciduous Teeth on Clinical Diseases: A Narrative Review Study","volume":"11","author":"Naderi F.","year":"2022","journal-title":"American Journal of Stem Cells"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2022.01.002"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.12677\/jcpm.2025.43353"},{"key":"e_1_2_13_13_1","first-page":"660","article-title":"Jiarong Tablet Plus Clomiphene in Infertility Treatment: 30\u2010Case Analysis","volume":"26","author":"Li A. 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