{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:01:20Z","timestamp":1784700080536,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Vitamin D deficiency has been proposed as a potential contributor to insulin resistance (\n IR<\/jats:styled-content>\n ) in polycystic ovary syndrome (\n PCOS<\/jats:styled-content>\n ); however, the evidence remains inconclusive. This meta\u2010analysis evaluated the association between serum 25\u2010hydroxyvitamin D [25(\n OH<\/jats:styled-content>\n )D] and\n IR<\/jats:styled-content>\n in\n PCOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We systematically searched\n PubMed<\/jats:styled-content>\n , Embase, Web of Science, and Cochrane Library up to December 2025 for observational studies reporting correlations of 25(\n OH<\/jats:styled-content>\n )D with\n IR<\/jats:styled-content>\n indices (\n HOMA<\/jats:styled-content>\n \u2010\n IR<\/jats:styled-content>\n \/fasting insulin) in women with\n PCOS<\/jats:styled-content>\n . Pooled correlation coefficients (\n r<\/jats:italic>\n ) with 95% confidence intervals (\n CI<\/jats:styled-content>\n ) were calculated using random\u2010effects models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fourteen studies involving 1856 women with\n PCOS<\/jats:styled-content>\n were included. A significant inverse correlation was found between serum 25(\n OH<\/jats:styled-content>\n )D and\n IR<\/jats:styled-content>\n (pooled\n r<\/jats:italic>\n \u2009=\u2009\u22120.32, 95%\n CI<\/jats:styled-content>\n : \u22120.40 to \u22120.23;\n p<\/jats:italic>\n \u2009<\u20090.001;\n \n I<\/jats:italic>\n 2<\/jats:sup>\n <\/jats:styled-content>\n \u2009=\u200958%). Subgroup analyses revealed stronger associations in overweight\/obese women (\n r<\/jats:italic>\n \u2009=\u2009\u22120.35) and in Asian populations (\n r<\/jats:italic>\n \u2009=\u2009\u22120.36). Women with vitamin D deficiency (<\u200920\u2009ng\/\n mL<\/jats:styled-content>\n ) showed a stronger correlation (\n r<\/jats:italic>\n \u2009=\u2009\u22120.38). Sensitivity analysis confirmed robustness, and no significant publication bias was detected.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Lower serum vitamin D is significantly associated with greater insulin resistance in\n PCOS<\/jats:styled-content>\n , especially in overweight\/obese and Asian subgroups. These findings highlight the potential value of assessing vitamin D status in the metabolic evaluation of\n PCOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70393","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:14:29Z","timestamp":1782972869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum Vitamin D Levels and Insulin Resistance in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Qingmin","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qinghai Provincial People's Hospital Xining Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qinghai Provincial People's Hospital Xining Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunming","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Massage Xining Hospital of Traditional Chinese Medicine Xining Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7132-3929","authenticated-orcid":false,"given":"Shujuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qinghai Provincial People's Hospital Xining Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00516-3"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"264","article-title":"Polycystic Ovary Syndrome: Common Questions and Answers","volume":"107","author":"Williams T.","year":"2023","journal-title":"American Family Physician"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"77","article-title":"Diagnostic Criteria for Polycystic Ovary Syndrome: Towards a Rational Approach","volume":"21","author":"Zawadzki J. 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