{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:56:05Z","timestamp":1791140165714,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cervical cancer (CC) is a major public health issue threatening women's health, and its early diagnosis and prognosis evaluation are very important. miR\u2010483\u20105p has been identified as an oncogene in multiple cancers, but its molecular mechanism in CC is still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore the biological functions and regulatory mechanisms of miR\u2010483\u20105p in CC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>miR\u2010483\u20105p expression levels in CC were detected by qRT\u2010PCR. The prognostic value of miR\u2010483\u20105p was established via Kaplan\u2013Meier survival analysis and Cox regression analysis. CCK\u20108 and Transwell assays served to analyze its regulatory effects on CC cell proliferation, migration, and invasion. Dual luciferase reporter assay validated the targeted binding relationship between miR\u2010483\u20105p and TIMP2. Co\u2010inhibition assays investigated the molecular mechanism of miR\u2010483\u20105p in CC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      miR\u2010483\u20105p is significantly increased in CC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and correlates with LNM, differentiation, tumor size, and FIGO stage. Elevated miR\u2010483\u20105p was an independent factor of poor survival in CC (HR\u2009=\u20099.942, 95% CI\u2009=\u20094.395\u201322.488). miR\u2010483\u20105p inhibitors significantly suppressed CC cell malignant progression. TIMP2 as a direct target of miR\u2010483\u20105p. miR\u2010483\u20105p accelerated CC development by inhibiting TIMP2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>miR\u2010483\u20105p is significantly overexpressed in CC and functions as an oncogene by directly targeting and suppressing TIMP2 expression, thereby promoting cancer cell malignant progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70396","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:49:07Z","timestamp":1784857747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Expression and Clinical Value of\n                    <scp>miR<\/scp>\n                    \u2010483\u20105p in Cervical Cancer and Its Regulation of Cervical Cancer via\n                    <scp>TIMP2<\/scp>"],"prefix":"10.1111","volume":"52","author":[{"given":"Yang","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, People's Hospital of Ningxia Hui Autonomous Region Ningxia Medical University  Yinchuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Changzhou Cancer Hospital  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology Dianshan Lake People's Hospital  Kunshan Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5941-7195","authenticated-orcid":false,"given":"Sanying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Health Examination Longyan People's Hospital  Longyan Fujian 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