{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:56:05Z","timestamp":1791140165633,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate pregnancy, peripartum, neonatal, and oncologic outcomes in pregnant patients with cervical cancer treated with neoadjuvant paclitaxel\u2013carboplatin chemotherapy followed by cesarean radical hysterectomy (CRH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective single\u2010center study included nine pregnant women diagnosed with histologically confirmed cervical cancer during pregnancy who received neoadjuvant chemotherapy and subsequently underwent CRH between 2011 and 2023. Maternal clinical characteristics, chemotherapy\u2010related toxicities, surgical outcomes, placental pathology, and neonatal outcomes were reviewed. Disease\u2010free survival and overall survival were descriptively assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median gestational age at diagnosis was 14.1\u2009weeks (range, 4.2\u201328.1\u2009weeks). All patients received paclitaxel\u2013carboplatin chemotherapy after the first trimester (median, three cycles). The median gestational age at CRH was 33.5\u2009weeks (range, 30.6\u201336.3\u2009weeks). Median estimated blood loss was 1800\u2009mL, and most patients required perioperative transfusion. Placental examination frequently demonstrated maternal underperfusion. One infant was small for gestational age, and most neonates were admitted to the NICU for prematurity\u2010related monitoring; all complications resolved without long\u2010term sequelae. During a median follow\u2010up of 62\u2009months, no recurrence or death was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neoadjuvant paclitaxel\u2013carboplatin chemotherapy followed by CRH allowed continuation of pregnancy until delivery in this small cohort of patients with cervical cancer during pregnancy. Despite frequent NICU admission, prematurity\u2010related complications, and substantial surgical morbidity, neonatal complications were mostly transient and long\u2010term oncologic outcomes appeared reassuring. These findings support the feasibility of this multidisciplinary treatment approach in carefully selected patients who wish to continue their pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70403","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:30:17Z","timestamp":1784809817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neoadjuvant Paclitaxel\u2013Carboplatin Chemotherapy Followed by Cesarean Radical Hysterectomy in Pregnant Patients With Cervical Cancer: Obstetric, Neonatal, and Surgical Outcomes"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-5124","authenticated-orcid":false,"given":"Ok\u2010Ju","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Hye","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010Wha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2475-7123","authenticated-orcid":false,"given":"Jeoung\u2010Yeol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-4954","authenticated-orcid":false,"given":"Mi\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-0680","authenticated-orcid":false,"given":"Jin Hoon","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Sung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of Ulsan College of Medicine, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.11.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2023.34.e39"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176308"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2025.264"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz228"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(11)60829\u20105"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds170"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq039"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181a44ca9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.08.001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.04.027"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2015.1065235"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29080450"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2014.57.6.539"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5387"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.06.003"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.23.2801"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2350\/08\u201003\u20100435.1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.03.002"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002264"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.033"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.ejgo.2021.02.2346"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.01.011"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.230"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:34:49Z","timestamp":1787650489000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jog.70403"],"URL":"https:\/\/doi.org\/10.1111\/jog.70403","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70403"}}