{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:19:58Z","timestamp":1787653198882,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2508085MH197"],"award-info":[{"award-number":["2508085MH197"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the suitability of intracytoplasmic sperm injection (ICSI) and in\u00a0vitro fertilization (IVF) for infertile couples with teratozoospermia primarily caused by sperm head abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 856 infertile couples with teratozoospermia. Patients were stratified into four groups by sperm head malformation type and severity: head acrosome malformation &lt;\u200995%\/&gt;\u200997%, and head shape malformation &lt;\u200995%\/&gt;\u200997%. Key outcomes (fertilization rate, 2PN fertilization\/cleavage rates, blastocyst formation\/high\u2010quality blastocyst rates, pregnancy\/live birth rates) were compared across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the head shape malformation &lt;\u200995% subgroup, IVF had higher fertilization and blastocyst formation rates. IVF also achieved a significantly higher fertilization rate in the head acrosome malformation &lt;\u200995% subgroup (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). ICSI yielded a higher proportion of high\u2010quality blastocysts in the head acrosome malformation &gt;\u200997% subgroup. No significant differences in 2PN fertilization\/cleavage rates, pregnancy rates, or live birth rates were observed between IVF and ICSI across all subgroups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IVF is preferred for sperm head abnormality rate &lt;\u200995% to enhance fertilization efficiency, while ICSI is advisable for acrosome malformation &gt;\u200997% to improve high\u2010quality embryo yield, providing evidence\u2010based guidance for individualized assisted reproductive technology (ART) selection.<\/jats:p>\n                  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