{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:20:04Z","timestamp":1787653204841,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Self\u2010collection models are regarded as a potential strategy to facilitate HPV testing for cervical cancer screening. HPV testing using urine specimens offers certain advantages, including its noninvasiveness. This characteristic has the potential to eliminate discomfort. Concerns regarding the accuracy of this method persist. Thus, the present meta\u2010analysis aims to verify the accuracy of HPV testing using self\u2010collected urine samples and vaginal samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted in the PubMed, Embase, and Cochrane Library databases to identify eligible studies. The inclusion criteria were as follows: studies that evaluated the diagnostic accuracy of HPV testing for high\u2010grade squamous intraepithelial lesion or worse (HSIL+) with self\u2010collected urine samples and vaginal samples. Additionally, studies that provided sufficient data for conducting a meta\u2010analysis were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The meta\u2010analysis was conducted using a bivariate random\u2010effects model. A total of 11 articles were identified. These articles included 3534 self\u2010collected urine specimens and 3523 vaginal specimens. The meta\u2010analysis yielded a pooled sensitivity of 81% for HPV testing with self\u2010collected urine specimens for HSIL+. A further meta\u2010analysis yielded a pooled sensitivity of 88.6% for HPV testing with self\u2010collected vaginal specimens detecting HSIL+. For specimen type, pooled sensitivity was 86.6% in the subgroup of papers using first void urine (FVU) via a standardized device to evaluate HPV testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta\u2010analysis suggests that HPV testing using both self\u2010collected urine and vaginal specimens achieves high sensitivity for detecting HSIL+. Another potential benefit of HPV testing employing FVU collected with a standardized device is the capacity for heightened sensitivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70434","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:55:31Z","timestamp":1785819331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of\n                    <scp>HPV<\/scp>\n                    Testing Using Self\u2010Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Ke\u2010Yu","family":"Hsiao","sequence":"first","affiliation":[{"name":"Department of Anatomical Pathology Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Ling","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nursing Landseed International Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-856X","authenticated-orcid":false,"given":"Cheng\u2010Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Saint Paul's Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101842"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01493-24"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.10400"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4823"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-022-02238-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4126"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5264"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2018.11.008"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgc.2025.101904"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.19163"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13928"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.09.040"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-022-01788-2"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2025.08.018"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70273"},{"issue":"2","key":"e_1_2_12_18_1","first-page":"143","article-title":"The Utility of an Human Papillomavirus Genotype Assay for Cancer Screening in Self\u2010Collected Urine and Vaginal Samples From Japanese Women","volume":"90","author":"Mizuno M.","year":"2025","journal-title":"Gynecologic and Obstetric Investigation"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70079"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2024.105737"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2023.09.008"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041512"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01443-19"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.02.002"},{"issue":"8","key":"e_1_2_12_25_1","first-page":"4183","article-title":"Vaginal and Urine Self\u2010Sampling Compared to Cervical Sampling for HPV\u2010Testing With the Cobas 4800 HPV Test","volume":"37","author":"Asciutto K. 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