{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:31:38Z","timestamp":1792503098879,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder that affects 5%\u201310% of women of reproductive age. Supplements with potential anti\u2010inflammatory properties, such as\n \n Nigella sativa<\/jats:italic>\n <\/jats:styled-content>\n oil, have been proposed as adjunctive therapies that may improve selected metabolic and inflammatory features of PCOS.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This study investigated the effect of\n \n N. sativa<\/jats:italic>\n <\/jats:styled-content>\n oil on serum levels of IL\u20106 and insulin in patients with polycystic ovary syndrome.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n This study was a randomized, double\u2010blind, placebo\u2010controlled clinical trial conducted on 60 PCOS patients. Patients received either\n \n N. sativa<\/jats:italic>\n <\/jats:styled-content>\n oil supplementation (1000\u2009mg daily) or placebo for 12\u2009weeks. Intermenstrual interval, menstrual duration, fasting blood glucose, insulin, insulin resistance, and serum IL\u20106 levels were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sixty women with PCOS were randomized equally to the intervention and placebo groups. After baseline adjustment, serum IL\u20106 (adjusted mean difference \u22124.21; 95% CI \u22126.34 to \u22122.08;\n p<\/jats:italic>\n \u2009<\u20090.001) and fasting blood glucose (adjusted mean difference \u22128.16\u2009mg\/dL; 95% CI \u221212.73 to \u22123.58;\n p<\/jats:italic>\n \u2009<\u20090.001) were significantly lower in the\n \n N. sativa<\/jats:italic>\n <\/jats:styled-content>\n group than in the placebo group. No significant between\u2010group differences were observed for fasting insulin, HOMA\u2010IR, QUICKI, luteinizing hormone, or total testosterone. The intermenstrual interval was significantly shorter in the intervention group, whereas menstrual duration and other clinical manifestations showed no significant between\u2010group differences.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Twelve weeks of\n \n N. sativa<\/jats:italic>\n <\/jats:styled-content>\n oil supplementation were associated with significant improvements in inflammatory status and fasting blood glucose compared with placebo after baseline adjustment. However, no significant between\u2010group effects were observed for insulin resistance indices or hormonal outcomes. These findings support the potential adjunctive role of\n \n N. sativa<\/jats:italic>\n <\/jats:styled-content>\n oil in PCOS while highlighting the need for larger adequately powered clinical trials.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70442","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:33:12Z","timestamp":1786757592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nigella sativa<\/i>\n (Black Seed) Oil Alleviates the Serum Levels of\n IL<\/scp>\n \u20106 and Insulin in Patients With Polycystic Ovary Syndrome"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8184-8800","authenticated-orcid":false,"given":"Samaneh","family":"Jamshidian","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, School of Medicine Ardabil University of Medical Sciences Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7557-8988","authenticated-orcid":false,"given":"Faranak","family":"Jalilvand","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, School of Medicine Ardabil University of Medical Sciences Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/pp9.0000000000000028"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0173-x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.01.001"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.11.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05951-2"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_576_17"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29912"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13092938"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416641-7.00030-4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3831\/KPI.2017.20.021"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2020.100404"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818553-7.00024-3"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.03.011"},{"issue":"1","key":"e_1_2_13_15_1","first-page":"48","article-title":"Effect of High\u2010Fat Diet on Tracheal Responsiveness to Methacholine and Insulin Resistance Index in Ovalbumin\u2010Sensitized Male and Female Rats","volume":"18","author":"Ghobadi H.","year":"2019","journal-title":"Iranian Journal of Allergy, Asthma, and Immunology"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16244911"},{"issue":"11","key":"e_1_2_13_17_1","first-page":"4716","article-title":"Assessing the Effect of Processed \n Nigella sativa\n on Oligomenorrhea and Amenorrhea in Patients With Polycystic Ovarian Syndrome: A Pilot Study","volume":"9","author":"Naeimi S. 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