{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:20:06Z","timestamp":1787653206740,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the utility of ophthalmic artery Doppler (OAD) indices, combined with maternal clinical factors, mean arterial pressure (MAP), and uterine artery pulsatility index (UtA\u2010PI), for the prediction of preeclampsia (PE) in a high\u2010risk obstetric population at 18\u201324\u2009weeks of gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospective cohort study conducted at a tertiary referral unit (UMAE HGO\u2013CMNO, IMSS, Guadalajara, Mexico) from January to December 2025. Singleton pregnancies with at least one major or two minor PE risk factors per NICE\/ACOG guidelines were included. Assessments comprised MAP (bilateral brachial), UtA\u2010PI (transabdominal Doppler), and OAD quantified as the second\u2010to\u2010first peak systolic velocity ratio (R\u2010PSV\n                      <jats:sub>1\u20132<\/jats:sub>\n                      ) via convex transducer over the right eye; R\u2010PSV\n                      <jats:sub>1\u20132<\/jats:sub>\n                      \u2009&gt;\u20090.60 was defined as abnormal. Hierarchical logistic regression models and ROC analysis were constructed; significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 182 women included, 81 had abnormal OAD and 101 had normal OAD. Overall, PE occurred in 24 (13.2%): 20\/81 (24.7%) in the abnormal group versus 4\/101 (4.0%) in the normal group (OR 7.95, 95% CI 2.59\u201324.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). All 16 early\u2010onset PE cases (&lt;\u200934\u2009weeks) arose exclusively in the abnormal OAD group (sensitivity 100%, NPV 100%). The full model (clinical\u2009+\u2009MAP\u2009+\u2009UtA\u2010PI\u2009+\u2009OAD) achieved an AUC of 0.815 (95% CI 0.698\u20130.909), superior to the clinical\u2010only model (AUC 0.722). In multivariable analysis, abnormal OAD was the strongest independent predictor (adjusted OR, 6.49; 95% CI 1.91\u201322.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OAD at 18\u201324\u2009weeks significantly improves PE prediction in high\u2010risk pregnancies beyond conventional risk factors. Its perfect sensitivity and NPV for early\u2010onset PE support its integration into multiparametric second\u2010trimester screening protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70449","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:38:14Z","timestamp":1786581494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ophthalmic Artery Doppler Indices and Maternal Factors in the Prediction of Preeclampsia in a High\u2010Risk Obstetric Population: A Prospective Cohort Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Giselle Odette","family":"Noyola\u2010Land\u00e1zuri","sequence":"first","affiliation":[{"name":"UMAE Hospital de Ginecoobstetricia, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-1595","authenticated-orcid":false,"given":"Francisco Javier","family":"Castro\u2010Apodaca","sequence":"additional","affiliation":[{"name":"Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde  Guadalajara Jalisco Mexico"},{"name":"School of Nutrition, Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n Jafit","family":"Gonz\u00e1lez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"UMAE Hospital de Ginecoobstetricia, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Manuel","family":"Mart\u00ednez\u2010Vera","sequence":"additional","affiliation":[{"name":"UMAE Hospital de Ginecoobstetricia, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social  Guadalajara Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Mar\u00eda","family":"Pe\u00f1a\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"School of Nutrition, Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidia","family":"Leon\u2010Sicairos","sequence":"additional","affiliation":[{"name":"School of Medicine, Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8605-0639","authenticated-orcid":false,"given":"Adrian","family":"Canizalez\u2010Roman","sequence":"additional","affiliation":[{"name":"School of Medicine, Autonomous University of Sinaloa  Culiacan Sinaloa Mexico"},{"name":"The Women's Hospital, Secretariat of Health  Culiacan Sinaloa 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