{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:19:55Z","timestamp":1787653195802,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Abortus imminens is a common condition in early pregnancy characterized by vaginal bleeding with a closed cervix and viable intrauterine pregnancy. Current biochemical markers have limited accuracy in predicting pregnancy outcomes. ELABELA (also known as Apela or Toddler), a peptide involved in angiogenesis and placental development, may serve as a potential biomarker in early pregnancy complications. This study aimed to evaluate maternal serum ELABELA levels in pregnancies diagnosed with abortus imminens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cross\u2010sectional study included 45 pregnant women diagnosed with abortus imminens between 8 and 14\u2009weeks of gestation and 45 healthy controls. Maternal serum ELABELA levels were measured using enzyme\u2010linked immunosorbent assay (ELISA). All serum samples were analyzed simultaneously in a single analytical batch to minimize interassay variability. Statistical analyses included group comparisons, receiver operating characteristic (ROC) curve analysis, and binary logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no significant differences between groups in terms of age, body mass index (BMI), gestational age at sampling, gravidity, or parity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). ELABELA levels were significantly lower in the abortus imminens group compared with controls (median: 649.82 vs. 859.60\u2009pg\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). ROC analysis demonstrated modest discriminative ability (area under the curve [AUC]\u2009=\u20090.641; 95% confidence interval [CI]: 0.520\u20130.751), with an optimal cut\u2010off value of 712.0\u2009pg\/mL (sensitivity 60.0%, specificity 68.9%). Logistic regression analysis showed no independent predictive value for ELABELA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal serum ELABELA levels are significantly reduced in pregnancies with abortus imminens, suggesting a potential role in early placental dysfunction. Although ELABELA alone may not be a strong independent predictor, it may serve as a complementary biomarker in the evaluation of abortus imminens. Further large\u2010scale prospective studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70450","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:15:01Z","timestamp":1786666501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Maternal Serum\n                    <scp>ELABELA<\/scp>\n                    Levels in Pregnancies Diagnosed With Abortus Imminens Between 8 and 14\u2009Weeks of Gestation"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3241-9984","authenticated-orcid":false,"given":"Simge","family":"\u00d6zgedik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3182-6430","authenticated-orcid":false,"given":"Metehan","family":"Herg\u00fcner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5848-1467","authenticated-orcid":false,"given":"Alihan","family":"Dura\u00e7e","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0198-8956","authenticated-orcid":false,"given":"\u00c7a\u011fda\u015f Necati","family":"Al","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-1926","authenticated-orcid":false,"given":"Ecem","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-4625","authenticated-orcid":false,"given":"\u00c7a\u011fda\u015f","family":"\u00d6zg\u00f6k\u00e7e","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7199","authenticated-orcid":false,"given":"\u0130brahim","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Sciences, Umraniye Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005943.pub5"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010013\u20102979\u20105"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000206186.91335.9a"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.19043"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.2.161"},{"issue":"4","key":"e_1_2_13_7_1","first-page":"233","article-title":"Management of Threatened Abortion","volume":"2","author":"Szab\u00f3 I.","year":"1996","journal-title":"Early Pregnancy"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mefs.2013.04.001"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.11.002"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010150"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4452"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2019.03.003"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2021.102127"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2013.813535"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2022.2090539"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248636"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010021\u201002790\u20101"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1276488"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002591"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2021.170674"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.21608\/zumj.2025.434838.4274"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.06.007"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1739264"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201055650\u20105"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:33:53Z","timestamp":1787650433000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jog.70450"],"URL":"https:\/\/doi.org\/10.1111\/jog.70450","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70450"}}