{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:19:55Z","timestamp":1787653195987,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Patients with preoperatively diagnosed venous thromboembolism (VTE) present complex management challenges, and optimal strategies for gynecological surgery remain unclear. Because malignancy is a major risk factor for VTE, perioperative management and outcomes may differ between malignant and benign gynecological diseases. This study aimed to compare perioperative management and short\u2010term outcomes between these groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective observational study included 1406 patients with preoperatively diagnosed VTE undergoing gynecological surgery between 2020 and 2022 using the Japanese Society of Anesthesiologists database. Patients were divided into malignant (M\u2010group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091126) and benign (B\u2010group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009280) groups. Clinical characteristics, treatment strategies, and postoperative outcomes within 28\u2009days after surgery were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1406 patients, 421 (29.9%) had pulmonary embolism, 161 (11.5%) had proximal deep vein thrombosis (DVT), and 824 (58.6%) had distal DVT. Direct oral anticoagulants were the most commonly used preoperative anticoagulants (61.3%), followed by unfractionated heparin (24.8%). Postoperative anticoagulation was more frequent in the M\u2010group than in the B\u2010group (57.5% vs. 44.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The 28\u2010day all\u2010cause mortality (1.2% vs. 0.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.752), VTE recurrence (2.0% vs. 2.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.406), and major bleeding (1.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.220) were comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides real\u2010world data on perioperative management and short\u2010term outcomes in gynecological surgical patients with preoperatively diagnosed VTE in Japan. Prospective studies are required to establish optimal, risk\u2010stratified perioperative management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70452","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T01:43:37Z","timestamp":1786671817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Management and Outcomes of Preoperatively Diagnosed Venous Thromboembolism in Gynecological Surgery: A Multicenter Retrospective Study Based on 2020\u20132022 Data From the Japanese Society of Anesthesiologists"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-9236","authenticated-orcid":false,"given":"Ryuji","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Kashihara Nara Japan"},{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists  Kobe Japan"},{"name":"The Scientific and Standardization Committee of the Japanese Society on Thrombosis and Hemostasis  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoi","family":"Sugimura","sequence":"additional","affiliation":[{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists  Kobe Japan"},{"name":"The Scientific and Standardization Committee of the Japanese Society on Thrombosis and Hemostasis  Tokyo Japan"},{"name":"Department of Obstetrics, Gynecology and Family Medicine, School of Medicine Hamamatsu University  Hamamatsu Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-2782","authenticated-orcid":false,"given":"Reiko","family":"Neki","sequence":"additional","affiliation":[{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists  Kobe Japan"},{"name":"The Scientific and Standardization Committee of the Japanese Society on Thrombosis and Hemostasis  Tokyo Japan"},{"name":"Division of Counseling for Medical Genetics National Cerebral and Cardiovascular Center  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2583-1321","authenticated-orcid":false,"given":"Yugo","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists  Kobe Japan"},{"name":"The Scientific and Standardization Committee of the Japanese Society on Thrombosis and Hemostasis  Tokyo Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Masui","sequence":"additional","affiliation":[{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists  Kobe Japan"},{"name":"Department of Anesthesiology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-0201","authenticated-orcid":false,"given":"Chikashi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists  Kobe Japan"},{"name":"Department of Anesthesia Kyoto University Hospital  Kyoto Japan"},{"name":"Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pulmonary Embolism Working Group of the Japanese Society of Anesthesiologists","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"Prevention of Venous Thromboembolism. 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