{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:19:55Z","timestamp":1787653195773,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the correlation between angiopoietin\u2010like protein 8 (ANGPTL8) and polycystic ovary syndrome (PCOS) and explore the clinical diagnostic value of ANGPTL8 in PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective case\u2013control study, we included 94 PCOS patients (study group) from our hospital's Reproductive Center from June 2023 to December 2024 and 116 age\u2010matched women with normal ovarian function (control group) from the Gynecology Department. Serum levels of anti\u2010M\u00fcllerian hormone (AMH), sex hormones, and ANGPTL8 were measured in all participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study group exhibited higher AMH, LH, LH\/FSH ratio, and E2 levels compared to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Serum ANGPTL8 levels were lower in PCOS patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Logistic multivariate regression analysis identified BMI, AMH, LH, and ANGPTL8 as independent influencing factors for PCOS. Elevated ANGPTL8 levels were associated with reduced PCOS risk (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while increased BMI, AMH, and LH levels correlated with higher PCOS risk (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). At a cutoff value of 12.871\u2009ng\/mL, ANGPTL8 demonstrated a sensitivity of 90.4%, specificity of 77.6%, and an area under the curve (AUC) of 0.881 (95% CI: 0.836\u20130.926,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), indicating moderate\u2010to\u2010high diagnostic efficacy. The combined use of ANGPTL8 with AMH or sex hormones improved diagnostic performance compared to individual markers. Notably, the combination of ANGPTL8 and sex hormones yielded a higher AUC (0.980) than ANGPTL8 with AMH (AUC\u2009=\u20090.928).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum ANGPTL8 levels are significantly lower in PCOS patients and inversely associated with PCOS risk. ANGPTL8 shows promise as a novel diagnostic biomarker for PCOS, especially when integrated into multi\u2010marker panels with existing hormonal parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70455","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:07:56Z","timestamp":1786709276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum\n                    <scp>ANGPTL8<\/scp>\n                    Levels and\n                    <scp>PCOS<\/scp>\n                    and Its Clinical Utility in Diagnosis"],"prefix":"10.1111","volume":"52","author":[{"given":"Yanli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Mental Health The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongbo","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Mental Health The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9120-547X","authenticated-orcid":false,"given":"Yuxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Hospital of Hebei Medical University  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002698"},{"issue":"6","key":"e_1_2_12_3_1","first-page":"1125","article-title":"Measuring the Global Disease Burden of Polycystic Ovary Syndrome in 194 Countries: Global Burden of Disease Study 2017","volume":"38","author":"Liu J.","year":"2023","journal-title":"Human Reproduction"},{"issue":"3","key":"e_1_2_12_4_1","first-page":"259","article-title":"Analysis of the Incidence Trend of Polycystic Ovary Syndrome in China From 1990 to 2019","volume":"24","author":"Liu L. 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