{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:07:30Z","timestamp":1790125650078,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate menstrual recovery, reproductive outcomes, and survival following fertility\u2010sparing surgery and platinum\u2010based chemotherapy in women with malignant ovarian germ cell tumors (MOGCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed women aged 15\u201340\u2009years with MOGCT treated at a university hospital (2001\u20132012). All underwent fertility\u2010sparing surgery and platinum\u2010based chemotherapy. Menstrual and reproductive outcomes were assessed through structured interviews and compared with age\u2010matched controls. Survival outcomes were analyzed by Kaplan\u2013Meier method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1934 ovarian cancer cases, 209 (10.8%) were MOGCT; 44 patients met inclusion criteria and were matched to 44 controls. Median age was 21\u2009years; dysgerminoma was the most common histology (40.9%), and 70.4% had Stage I disease. All received bleomycin, etoposide, and cisplatin (median 4\u2009cycles). After a median follow\u2010up of 55\u2009months, 97.7% resumed menstruation. Compared with baseline and controls, cycles were shorter (4 vs. 5\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), lighter (2 vs. 3\u2009pads\/day,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004\u20130.047), and longer in interval (29.2 vs. 26.4\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Of 17 patients attempting conception, 9 achieved 10 pregnancies, with a pregnancy rate of 52.9% and live\u2010birth rate of 90.9%, without congenital anomalies. Only one recurrence occurred, with 10\u2010year progression\u2010free and overall survival of 95.3% and 97.9%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fertility\u2010sparing surgery followed by platinum\u2010based chemotherapy was associated with excellent long\u2010term survival, high rates of menstrual recovery, and favorable reproductive outcomes in young women with MOGCT. These findings support current international recommendations for fertility\u2010preserving treatment in selected patients and provide long\u2010term evidence from a Southeast Asian cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70462","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:22:24Z","timestamp":1788528144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Menstrual Recovery and Reproductive Outcomes After Fertility\u2010Sparing Surgery and Adjuvant Chemotherapy for Malignant Ovarian Germ Cell Tumors: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3864-9430","authenticated-orcid":false,"given":"Aroontorn","family":"Pichatechaiyoot","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9096-3481","authenticated-orcid":false,"given":"Rakchai","family":"Buhachat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7632-9949","authenticated-orcid":false,"given":"Wanapa","family":"Naphatthalung","sequence":"additional","affiliation":[{"name":"Bangkok Rayong Center Hospital  Rayong Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-8975","authenticated-orcid":false,"given":"Nungrutai","family":"Saeaib","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-0751","authenticated-orcid":false,"given":"Kanet","family":"Kanjanapradit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2012.01.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.8738"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.11.1950"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds223"},{"key":"e_1_2_11_6_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology: Ovarian Cancer. 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Y.","year":"2016","journal-title":"International Journal of Gynecological Cancer"},{"key":"e_1_2_11_17_1","volume-title":"SEER Cancer Statistics Review, 1973\u20132010","author":"Howlader N.","year":"2013"},{"issue":"1","key":"e_1_2_11_18_1","first-page":"151","article-title":"Malignant Ovarian Germ Cell Tumors in Japan: Clinical Aspects and Management","volume":"20","author":"Koshiyama M.","year":"2015","journal-title":"International Journal of Clinical Oncology"},{"issue":"5","key":"e_1_2_11_19_1","first-page":"1267","article-title":"Malignant Ovarian Germ Cell Tumors: Clinicopathological Presentation and\u00a0Survival Outcomes","volume":"11","author":"Tangjitgamol S.","year":"2010","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"19","key":"e_1_2_11_20_1","first-page":"2799","article-title":"Fertility\u2010Sparing Surgery for Malignant Ovarian Germ Cell Tumors","volume":"25","author":"Gershenson D. M.","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"e_1_2_11_21_1","first-page":"266","article-title":"Long\u2010Term Outcome and Fertility in Malignant Ovarian Germ Cell Tumors: A Multicenter, Retrospective Study of 144 Patients","volume":"152","author":"Mangili G.","year":"2019","journal-title":"Gynecologic Oncology"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746\u2010019\u20100139\u20104"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941738112469930"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70462","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70462","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:52:16Z","timestamp":1790124736000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jog.70462"],"URL":"https:\/\/doi.org\/10.1111\/jog.70462","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70462"}}