{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:06:18Z","timestamp":1790125578106,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n High\u2010risk HPV screening achieves high sensitivity but low specificity, resulting in excessive colposcopy referrals. DNA methylation biomarkers could refine risk stratification across the cervical cancer care continuum.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the diagnostic performance and clinical implementation of DNA methylation testing in HPV\u2010positive triage and post\u2010treatment surveillance.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Narrative review of prospective cohorts and randomized trials (2013\u20132024) evaluating methylation markers in cervical cancer screening and monitoring.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The FAM19A4\/miR124\u20102 panel demonstrated sensitivity\/specificity of 0.83\/0.90 for CIN3+ in HPV\u2010positive women, reducing colposcopy referrals by 45% while maintaining <\u20093% missed CIN3+. In post\u2010treatment surveillance, plasma cell\u2010free DNA (cfDNA) methylation may enable earlier recurrence detection than imaging (sensitivity 0.81, specificity 0.93, based on limited prospective data). A proposed three\u2010step conceptual framework integrating methylation testing across screening, postoperative assessment, and recurrence monitoring is presented as a hypothesis\u2010generating model requiring prospective validation.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n DNA methylation testing shows promise for clinical implementation in HPV triage and post\u2010treatment surveillance. Evidence remains fragmented across separate studies. Standardization of thresholds and cost reduction are priorities for guideline inclusion.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70473","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:13:31Z","timestamp":1788326011000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNA<\/scp>\n Methylation Testing in Cervical Cancer: A Triage Tool for\n HPV<\/scp>\n \u2010Based Screening and Post\u2010Treatment Surveillance"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4311-5735","authenticated-orcid":false,"given":"Yuance","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jilin Women and Children Health Hospital (Jilin Province Maternal and Child Health Quality Control Center) Changchun 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