{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:06:57Z","timestamp":1790125617718,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic histiocytic intervillositis (CHI) is a rare placental disorder linked to poor pregnancy outcomes, including fetal growth restriction and perinatal loss. We report a case of recurrent CHI in a 36\u2010year\u2010old woman with five previous pregnancy losses. In her sixth pregnancy, placental histology confirmed CHI after preterm delivery. In a subsequent seventh pregnancy, despite early treatment with aspirin, low\u2010molecular weight heparin, and hydroxychloroquine, she developed uteroplacental dysfunction at 17\u2009weeks with hypertension, proteinuria, and transaminitis. Rescue therapy with high\u2010dose prednisolone led to maternal clinical improvement, stabilization of fetal Dopplers, and pregnancy prolongation to 30\u2009weeks. Placental histology showed a reduced inflammatory infiltrate compared to the prior pregnancy, suggesting a therapeutic effect from corticosteroids. This case reports the novel use of high\u2010dose corticosteroid rescue therapy in managing CHI and highlights the importance of early diagnosis, multidisciplinary care, and the need for further research.<\/jats:p>","DOI":"10.1111\/jog.70478","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:24:45Z","timestamp":1788841485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Dose Corticosteroids in Chronic Histiocytic Intervillositis Allowing Prolongation of Pregnancy: A Case Report"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6491-7446","authenticated-orcid":false,"given":"Arti","family":"Dave","sequence":"first","affiliation":[{"name":"Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Bryant","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlo","family":"Kwok","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Allen","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-7845","authenticated-orcid":false,"given":"Alexander","family":"Heazell","sequence":"additional","affiliation":[{"name":"University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-8144","authenticated-orcid":false,"given":"Kate","family":"Wiles","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"13","key":"e_1_2_12_2_1","article-title":"Chronic Histiocytic Intervillositis (CHI): Current Treatments and Perinatal Outcomes, a Systematic Review and a Meta\u2010Analysis","volume":"22","author":"Moar L.","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13373"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69191-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.11.012"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2024.104285"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10010168"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.06.003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.11.009"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.753220"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.01.001"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934794"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:52:13Z","timestamp":1790124733000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jog.70478"],"URL":"https:\/\/doi.org\/10.1111\/jog.70478","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70478"}}