{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:06:21Z","timestamp":1790125581063,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We compared outcomes and toxicities of weekly paclitaxel plus carboplatin\u2010based (wTC) and cisplatin\u2010based (CDDP) concurrent chemoradiotherapy (CCRT) in FIGO stage IB2\u2013IVA cervical cancer cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients with FIGO stage IB2\u2013IVA cervical cancer who underwent definitive\u2010intent CCRT at our institution between 2009 and 2024. To reduce temporal confounding, the primary analysis was restricted to 2015\u20132024, when both regimens were available, and a sensitivity analysis included the entire period. Progression\u2010free survival (PFS) and overall survival (OS) were evaluated using the Kaplan\u2013Meier method and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary analysis included 54 patients (wTC,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927; CDDP,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927). Baseline characteristics were balanced. The 3\u2010year PFS rates were 53.5% and 77.4% in the wTC and CDDP groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.078), and the 3\u2010year OS rates were 76.4% and 75.4%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.882). The treatment regimen was not significantly associated with OS, whereas tumor diameter \u2265\u20096\u2009cm was associated with worse OS. In the sensitivity analysis (wTC,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200984; CDDP,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927), PFS and OS did not differ significantly between groups. Creatinine increased\u00a0was more severe in the CDDP group, whereas neutropenia was more severe in the wTC group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No significant differences in survival outcomes were observed between wTC\u2010CCRT and CDDP\u2010CCRT in patients with FIGO stage IB2\u2013IVA cervical cancer. The study was not designed to establish equivalence or non\u2010inferiority. wTC\u2010CCRT may be considered for selected patients unable to receive cisplatin, although its comparative efficacy remains uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70489","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:23:34Z","timestamp":1788841414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Outcomes of Weekly Paclitaxel\u2013Carboplatin\u2010Based Chemoradiotherapy Versus Cisplatin\u2010Based Chemoradiotherapy for\n                    <scp>FIGO<\/scp>\n                    Stage\n                    <scp>IB2<\/scp>\n                    \u2013\n                    <scp>IVA<\/scp>\n                    Cervical cancer: A Retrospective Observational Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Ayano","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8839-4483","authenticated-orcid":false,"given":"Kenro","family":"Chikazawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University Saitama Medical Center  Saitama Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3942-4232","authenticated-orcid":false,"given":"Yukiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Radiology Jichi Medical University Saitama Medical Center  Saitama 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