{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:06:18Z","timestamp":1790125578087,"version":"4.0.1"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n Natural disasters may disrupt access to assisted reproductive technology (ART) services. This study evaluated the impact of the 2016 Kumamoto earthquake on ART utilization in Kumamoto Prefecture, accounting for nationwide trends and policy changes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted an interrupted time\u2010series analysis using annual ART subsidy application data in Kumamoto Prefecture from 2005 to 2020. Nationwide application counts were included as an offset to adjust for national trends related to the 2016 subsidy policy revision. Age\u2010specific patterns were also examined using normalized indices.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In analysis adjusted for nationwide trends, ART subsidy applications showed a significant immediate reduction in 2016 (incidence rate ratio [IRR]\u2009=\u20090.84, 95% confidence interval [CI]: 0.77\u20130.91), followed by a gradual recovery (IRR for slope change\u2009=\u20091.06, 95% CI: 1.04\u20131.09). The decline was more pronounced among women aged 40\u2009years and older, whereas applications among younger women remained relatively stable.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The 2016 Kumamoto earthquake was associated with a substantial decline in ART subsidy applications in Kumamoto Prefecture beyond nationwide trends. This reduction was most pronounced among women aged 40\u2009years and older, suggesting age\u2010related differences in responses to disaster\u2010related disruptions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.70498","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:18:59Z","timestamp":1789525139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of the 2016 Kumamoto Earthquake on\n ART<\/scp>\n Subsidy Applications in Kumamoto Prefecture: Interrupted Time\u2010Series Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6433-6609","authenticated-orcid":false,"given":"Rumi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Life Sciences Kumamoto University Kumamoto Japan"},{"name":"Department of Reproductive Health, Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-3243","authenticated-orcid":false,"given":"Takashi","family":"Ohba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Life Sciences Kumamoto University Kumamoto Japan"},{"name":"Department of Obstetrics and Gynecology JCHO Kumamoto General Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-672X","authenticated-orcid":false,"given":"Miwa","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-8290","authenticated-orcid":false,"given":"Kenyu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation Kumamoto University Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-3143","authenticated-orcid":false,"given":"Eiji","family":"Kondoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DMP.0b013e3181b66ae4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111066"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.03.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.05.068"},{"issue":"9","key":"e_1_2_12_6_1","first-page":"776","article-title":"Impact of the Great East Japan Earthquake and Fukushima Nuclear Power Plant Accident on Assisted Reproductive Technology in Fukushima Prefecture: The Fukushima Health Management Survey","volume":"9","author":"Hayashi M.","year":"2017","journal-title":"Journal of Clinical Medical Research"},{"key":"e_1_2_12_7_1","unstructured":"Ministry of Health Labour and Welfare (Japan) \u201cIndividual Issues (Infertility Treatment). Central Social Insurance Medical Council (Chuikyo) General Meeting No. 565. (Serial Online) \u201d(2023) https:\/\/www.mhlw.go.jp\/stf\/shingi2\/0000212500_00224.html."},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa032"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12620"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70498","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:52:04Z","timestamp":1790124724000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jog.70498"],"URL":"https:\/\/doi.org\/10.1111\/jog.70498","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70498"}}