{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:09:14Z","timestamp":1790125754761,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>High\u2010grade serous ovarian cancer is a deadly cancer with a poor prognosis. Serum microRNAs have been used to detect and diagnose various cancers. We aimed to investigate the prognostic impact of serum microRNA profiles pre\u2010, peri\u2010, and post\u2010primary treatment on the progression\u2010free survival of patients with advanced high\u2010grade serous ovarian cancer receiving neoadjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were prospectively recruited, and pre\u2010, peri\u2010, and post\u2010treatment blood samples were collected. MicroRNA microarray results, together with the clinical and surgical data, were analyzed using Cox regression with leave\u2010one\u2010out least absolute shrinkage and selection operator for progression\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 29 patients were included. A combined analysis of pre\u2010treatment serum microRNAs and clinical factors showed a higher c\u2010index (0.86) for distinguishing high\u2010 and low\u2010risk groups for poor progression\u2010free survival outcomes compared to analyzing each factor alone (0.70 and 0.64, respectively). The high\u2010risk group exhibited significantly worse progression\u2010free survival (log\u2010rank,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The serum microRNA profile at 3\u2009months post\u2010treatment showed outstanding discrimination (c\u2010index of 1.00). Changes in the microRNA profile between pre\u2010 and peri\u2010treatment had no prognostic impact; however, the difference between pre\u2010treatment and 3 months post\u2010treatment exhibited excellent discrimination (c\u2010index of 1.00).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with advanced high\u2010grade serous ovarian cancer who received neoadjuvant chemotherapy, a combination of the pre\u2010treatment serum microRNA profiles and clinical factors, or the 3\u2010month post\u2010treatment serum microRNA profile could distinguish between those in high\u2010 and low\u2010risk groups for poor progression\u2010free survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70500","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:26:13Z","timestamp":1789698373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of Serum\n                    <scp>microRNA<\/scp>\n                    Profiles on the Progression\u2010Free Survival of Patients With High\u2010Grade Serous Ovarian Cancer Receiving Neoadjuvant Chemotherapy"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0688-8827","authenticated-orcid":false,"given":"Takashi","family":"Uehara","sequence":"first","affiliation":[{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Obstetrics and Gynecology Chiba University Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-5049","authenticated-orcid":false,"given":"Juntaro","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Division of Interdisciplinary Genetics and Nanomedicine, Research Center for Drug Discovery Keio University Faculty of Pharmacy  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-8479","authenticated-orcid":false,"given":"Yusuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Oncology National Cancer Center Research Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-7813","authenticated-orcid":false,"given":"Hiroshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6948-4007","authenticated-orcid":false,"given":"Yuto","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Dynacom Co. Ltd.  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-0948","authenticated-orcid":false,"given":"Junichiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Dynacom Co. Ltd.  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-4414","authenticated-orcid":false,"given":"Hitoshi","family":"Fujimiya","sequence":"additional","affiliation":[{"name":"Dynacom Co. Ltd.  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-7863","authenticated-orcid":false,"given":"Satoko","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Toray Industries Inc.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-5102","authenticated-orcid":false,"given":"Akira","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-7611","authenticated-orcid":false,"given":"Kan","family":"Yonemori","sequence":"additional","affiliation":[{"name":"Department of Breast and Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-5072","authenticated-orcid":false,"given":"Ken","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Esophageal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8855-2966","authenticated-orcid":false,"given":"Mitsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gynecology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0776-9918","authenticated-orcid":false,"given":"Takahiro","family":"Ochiya","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Medicine, Institute of Medical Science Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21559"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104390"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103799"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.004"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.28620"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.2019-0011-OA"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12880"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1451"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4573"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13856"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06434-4"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0863-y"},{"key":"e_1_2_13_14_1","first-page":"114","article-title":"Identification of Serum microRNAs Predicting the Response of Esophageal Squamous\u2010Cell Carcinoma to Nivolumab","volume":"50","author":"Sudo K.","year":"2020","journal-title":"Japanese Journal of Clinical Oncology"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222024"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15154"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2020.07.021"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.795"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.340"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000846"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.11.005"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01925-0"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.01.0454"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70363-2"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03702"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.04.005"},{"key":"e_1_2_13_27_1","first-page":"4762","article-title":"Low miR\u2010498 Expression Levels Are Associated With Poor Prognosis in Ovarian Cancer","volume":"19","author":"Cong J.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-3411"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2023.34.e34"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-1162"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03358-0"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-021-00919-5"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:52:41Z","timestamp":1790124761000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jog.70500"],"URL":"https:\/\/doi.org\/10.1111\/jog.70500","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70500"}}