{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:58:08Z","timestamp":1790661488640,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is characterized by insulin resistance, hyperandrogenism, and reproductive dysfunction. Myoinositol and coenzyme Q10 (CoQ10) have complementary metabolic and hormonal effects; however, the additive and dose\u2010dependent effects of CoQ10 remain unclear. This study evaluated these effects in women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective study, 200 women with PCOS were assigned to four groups: myoinositol plus CoQ10 100\u2009mg (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955), myoinositol plus CoQ10 200\u2009mg (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200955), myoinositol alone (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945), and untreated controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200945). Fasting insulin, HOMA\u2010IR, total testosterone, and menstrual cycle regularity were assessed at baseline and 6\u2009months. Between\u2010group differences were evaluated using multivariable regression analyses and sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All treatment groups showed improvements in metabolic and hormonal parameters, with the greatest effects observed in the combination therapy groups. Myoinositol alone was associated with significant reductions in HOMA\u2010IR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.219;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and total testosterone (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22123.145;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared with untreated controls. The addition of CoQ10 resulted in dose\u2010dependent improvements, with 100 and 200\u2009mg doses demonstrating progressively greater reductions in HOMA\u2010IR (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.308 and \u22120.571, respectively) and total testosterone (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22122.847 and \u22125.325, respectively) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariable regression analyses confirmed that both CoQ10 doses remained significantly superior to myoinositol monotherapy. Menstrual cycle regularity improved most in the MI\u2009+\u2009CoQ10 200\u2009mg group (36.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjunctive CoQ10 supplementation with myoinositol provides significant and dose\u2010dependent improvements in insulin resistance and hyperandrogenism in PCOS. The magnitude of reduction observed with 200\u2009mg CoQ10 suggests potential clinical relevance, particularly in metabolically compromised patients. Prospective randomized studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.70502","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:13:13Z","timestamp":1790658793000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Additive and Dose\u2010Dependent Effects of Coenzyme Q10 Combined With Myoinositol on Insulin Resistance and Hyperandrogenism in Women With Polycystic Ovary Syndrome: A Retrospective Controlled Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-7501","authenticated-orcid":false,"given":"Burcu","family":"Dincgez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Bursa Yuksek Ihtisas Research and Training Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7888-7583","authenticated-orcid":false,"given":"Gulten","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bursa Yuksek Ihtisas Research and Training Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2902-9670","authenticated-orcid":false,"given":"Nergis Kender","family":"Erturk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Bursa Yuksek Ihtisas Research and Training Hospital  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-8825","authenticated-orcid":false,"given":"Hazel Cag\u0131n","family":"Kuzey","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Biruni University  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-5766","authenticated-orcid":false,"given":"Esra Kartal","family":"Golcuk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Memorial Sisli Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010025\u201001621\u20106"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad463"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020583"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010022\u201001091\u20100"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt\u20102022\u2010001989"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978\u2010021\u201001073\u20103"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241814126"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032\u2010022\u201001038\u20102"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.02.002"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14931"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.53951"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010023\u201001055\u2010z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad762"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.13668"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1991910"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1779689"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2025.11386"}],"container-title":["Journal 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