{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:01:31Z","timestamp":1790661691630,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A 38\u2010year\u2010old woman conceived after intracytoplasmic sperm injection and frozen\u2013thawed double blastocyst transfer. First\u2010trimester ultrasonography suggested monochorionic diamniotic twins, but discordant external genitalia were identified at 21\u2009weeks of gestation. Delivery at 37\u2009weeks resulted in phenotypically normal female and male infants. Placental histopathology confirmed monochorionic diamniotic placentation. Postnatal multimodal genetic evaluation, including G\u2010banding, single nucleotide polymorphism array, and buccal cell X\/Y fluorescence in\u00a0situ hybridization, demonstrated mixed 46,XX\/46,XY cell lines in peripheral blood, consistent with predominantly blood\u2010limited chimerism. Single nucleotide polymorphism array analysis demonstrated admixture of two independently derived genomes and findings inconsistent with a primary dispermic mechanism. These results supported a diagnosis of monochorionic dizygotic twinning with predominantly blood chimerism, most likely reflecting intertwin cell exchange. This case highlights the value of integrating tissue\u2010specific genetic findings with postnatal phenotypic and clinical assessment to interpret predominantly blood\u2010limited chimerism in MCDZ twins.<\/jats:p>","DOI":"10.1111\/jog.70512","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:21:36Z","timestamp":1790659296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Discordant Monochorionic Dizygotic Twins After Double Blastocyst Transfer: Blood Chimerism Demonstrated by Multimodal Genetic Testing"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7848-790X","authenticated-orcid":false,"given":"Kotaro","family":"Yuki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Sciences Kyushu University  Fukuoka 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