{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:40:33Z","timestamp":1792636833847,"version":"4.5.0"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a fatal case of malignant uterine tumor resembling ovarian sex cord tumor (UTROSCT) harboring the\n                    <jats:italic>GREB1::SS18<\/jats:italic>\n                    fusion gene. A 64\u2010year\u2010old woman presented with a uterine tumor extending into the inferior vena cava, along with multiple hepatic and bone metastases. Although imaging suggested low\u2010grade endometrial stromal sarcoma, histopathology revealed sex cord\u2010like structures.\n                    <jats:italic>GREB1::SS18<\/jats:italic>\n                    fusion was identified by RNA sequencing and independently confirmed by RT\u2010PCR and Sanger sequencing. Despite multimodal therapy, the patient died 26\u2009months postoperatively. While most UTROSCTs follow a benign course, rare malignant cases exist. Literature review suggests\n                    <jats:italic>GREB1<\/jats:italic>\n                    \u2010rearranged UTROSCTs are more aggressive, occurring in older patients with larger tumors compared to\n                    <jats:italic>ESR1<\/jats:italic>\n                    \u2010rearranged tumors. This is the first report of a fatal outcome associated with the\n                    <jats:italic>GREB1::SS18<\/jats:italic>\n                    fusion. This case underscores the importance of molecular diagnosis for predicting malignant potential in UTROSCT, especially when atypical aggressive features are present.\n                  <\/jats:p>","DOI":"10.1111\/jog.70522","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:30:22Z","timestamp":1791509422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive Clinical Course of Uterine Tumor Resembling Ovarian Sex Cord Tumor (\n                    <scp>UTROSCT<\/scp>\n                    ) Harboring\n                    <i>GREB1::SS18<\/i>\n                    Fusion Gene: A Case Report"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9951-9763","authenticated-orcid":false,"given":"Haruki","family":"Kasama","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Hospital  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kanazawa University Hospital  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9783-1534","authenticated-orcid":false,"given":"Daichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pathology Kanazawa University Graduate School of Medical Sciences  Kanazawa Japan"},{"name":"The Garvan Institute of Medical Research  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5131-2870","authenticated-orcid":false,"given":"Aki","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1885-6272","authenticated-orcid":false,"given":"Takashi","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Hospital  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9648-158X","authenticated-orcid":false,"given":"Kaoru","family":"Abiko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa University Hospital  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13296"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001265"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001348"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2023.11.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.70075"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.036"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000240"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.70522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.70522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:27:53Z","timestamp":1792636073000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.70522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/jog.70522"],"URL":"https:\/\/doi.org\/10.1111\/jog.70522","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70522"}}